ArticleCell reports2019
A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Prognosis and Clinical Significance of Piezo2 in Tumor: A Meta-analysis and Database Validation.Combinatorial chemistry & high throughput screening · 2024Pooled it
- Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates.eNeuro · 2025Article
- The inner core enables transient touch detection in the Pacinian corpuscle.Science advances · 2025Article
- 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle.Science advances · 2023Article
- Yoda1's energetic footprint on Piezo1 channels and its modulation by voltage and temperature.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of microRNA and gene expression in the cochlea of an echolocating bat (Ecology and evolution · 2022Article
- Tactile sensation in birds: Physiological insights from avian mechanoreceptors.Current opinion in neurobiology · 2022Review
- Comparative Genomics Provides Insights into Adaptive Evolution in Tactile-Foraging Birds.Genes · 2022Article
- Quantitative Evaluation of Tactile Foraging Behavior in Pekin and Muscovy Ducks.Frontiers in physiology · 2022Article
- A bibliometric analysis and review of recent researches on Piezo (2010-2020).Channels (Austin, Tex.) · 2021Review
- Article
- Lamellar cells in Pacinian and Meissner corpuscles are touch sensors.Science advances · 2020Article
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we studied somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavior. We found that tactile specialists exhibit a proportional expansion of neuronal mechanoreceptors in trigeminal ganglia. The expansion of mechanoreceptors occurs via neurons with intermediately and slowly inactivating mechanocurrent. Such neurons contain the mechanically gated Piezo2 ion channel whose expression positively correlates with the expression of factors responsible for the development and function of mechanoreceptors. Conversely, Piezo2 expression negatively correlates with expression of molecules mediating the detection of temperature and pain, suggesting that the expansion of Piezo2-containing mechanoreceptors with prolonged mechanocurrent occurs at the expense of thermoreceptors and nociceptors. Our study suggests that the trade-off between neuronal subtypes is a general mechanism of tactile specialization at the level of somatosensory system.
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