Evidence map›Paper›PMID 30784316›Full record

ArticleAIDS research and human retroviruses2019

Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV.

Lukasz D Weiner, Mauricio Retuerto, Christopher L Hager, Vanessa El Kamari, Lingpeng Shan, Abdus Sattar, Manjusha Kulkarni, Nicholas Funderburg, Mahmoud A Ghannoum, Sahera Dirajlal-Fargo and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Review
  6. Article
  7. Fungal translocation measured by serum 1,3-ß-D-glucan correlates with severity and outcome of liver cirrhosis-A pilot study.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
  8. Review
  9. Observational
  10. Article
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  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Effect of Opioid Use on Immune Activation and HIV Persistence on ART.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  19. Review
  20. Altered Intestinal Permeability and Fungal Translocation in Ugandan Children With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lukasz D Weiner1 Pediatric Infectious Diseases, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Mauricio Retuerto3 Case Western Reserve University, Cleveland, Ohio.
Christopher L Hager3 Case Western Reserve University, Cleveland, Ohio.
Vanessa El Kamari3 Case Western Reserve University, Cleveland, Ohio.
Lingpeng Shan3 Case Western Reserve University, Cleveland, Ohio.
Abdus Sattar3 Case Western Reserve University, Cleveland, Ohio.
Manjusha Kulkarni5 Ohio State University School of Health and Rehabilitation Sciences, Columbus, Ohio.
Nicholas Funderburg5 Ohio State University School of Health and Rehabilitation Sciences, Columbus, Ohio.
Mahmoud A Ghannoum3 Case Western Reserve University, Cleveland, Ohio.
Sahera Dirajlal-Fargo1 Pediatric Infectious Diseases, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Grace A McComsey1 Pediatric Infectious Diseases, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Case Western Reserve University · USRainbow Babies & Children's Hospital · USUniversity Hospitals of Cleveland · US

Funding

Cardiovascular disease and inflammation in Ugandan children with HIVK23HD088295 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI DIRAJLAL-FARGO, SAHERA · 2016 to 2020
$799k
Dysregulated arginine metabolism in treated HIV infectionR56HL126539 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2014 to 2014
$792k
Incremental effect of smoking on HIV immune activation and cardiac healthR56HL126526 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2014 to 2014
$788k
Tissue factor expression in HIV disease - Implications for cardiovascular riskR00HL108743 · NHLBI · OHIO STATE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2014 to 2016
$747k
Changes in gut integrity markers after HIV therapy and metabolic complicationsR21DK118757 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2019
$453k
NHLBI NIH HHS R00 HL108743NHLBI NIH HHS R56 HL126526NHLBI NIH HHS R56 HL126539NICHD NIH HHS K23 HD088295NIDDK NIH HHS R21 DK118757
6 · The paper itself

Abstract

The mechanisms causing HIV-associated immune activation remain incompletely understood. Alteration of intestinal integrity with subsequent translocation of bacterial products appears to play an important role; however, little is known about the impact of fungal translocation. We assessed the effect of fungal translocation and its association with immune activation in people living with HIV (PLWH) compared with uninfected controls. We measured serum levels of β-D-glucan (BDG) and anti-

Indexed as

InflammationLymphocyte ActivationAdultAntibodies, FungalAntiviral AgentsBiomarkersCohort StudiesCross-Sectional StudiesFemaleGlucansHIV InfectionsHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedAntibodies, FungalAntiviral AgentsBiomarkersGlucansImmunoglobulin AImmunoglobulin Gbiomarkersfungigastrointestinal microbiomeHIVinflammation

Identifiers

PMID30784316
PMCPMC6516070
OpenAlexW2916708351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.