ArticleJournal of cachexia, sarcopenia and muscle2019
Relative sarcopenia and mortality and the modifying effects of chronic kidney disease and adiposity.
Article in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Effects of pre-dialysis resistance training on sarcopenia, inflammatory profile, and anemia biomarkers in older community-dwelling patients with chronic kidney disease: a randomized controlled trial.International urology and nephrology · 2021Trial
- Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Association of immune checkpoint inhibitors with muscle mass and density in patients with melanoma.The oncologist · 2026Article
- Respiratory sarcopenia as a mortality predictor for chronic kidney disease: a dual-cohort longitudinal study.Renal failure · 2025Article
- Identification of biomarkers associated with glycolysis and lactation in sarcopenia.Scientific reports · 2025Article
- Association of possible sarcopenia and its components with all-cause mortality in a middle-aged and older population: a 9-year cohort study.Scientific reports · 2025Article
- Risks of All-Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Article
- Cystatin C Is a Predictor for Long-Term, All-Cause, and Cardiovascular Mortality in US Adults With Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2024Article
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- Article
- The impact of sarcopenia on the postoperative outcome in colorectal cancer surgery.Medicine and pharmacy reports · 2023Review
- Assessment of the components of sarcopenia and quality of life perceived of individuals on hemodialysis.Revista brasileira de enfermagem · 2023Article
- Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes.Journal of transplantation · 2023Review
- Reduced Skeletal Muscle Mass Is Associated with an Increased Risk of Asthma Control and Exacerbation.Journal of clinical medicine · 2022Article
- The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults.Journal of clinical medicine · 2022Review
- Serum creatinine to cystatin C ratio reflects preoperative and early postoperative walking ability in older patients with hip fracture.Journal of cachexia, sarcopenia and muscle · 2022Article
- Association of Fat Mass with SARC-F in Older Patients Undergoing Haemodialysis.The journal of nutrition, health & aging · 2022Article
- Changes in Body Composition, Muscle Strength, and Fat Distribution Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundConventional definitions of sarcopenia based on lean mass may fail to capture low lean mass relative to higher fat mass, that is, relative sarcopenia. The objective of this study is to determine the associations of sarcopenia and relative sarcopenia with mortality independent of co-morbidities, and whether chronic kidney disease (CKD) and adiposity alter these associations.
methodsDual energy X-ray absorptiometry-derived appendicular lean mass index (ALMI, kg/m
resultsThree (3.0) per cent of National Health and Nutrition Examination Survey participants met criteria for sarcopenia and 8.7% met criteria for relative sarcopenia. Sarcopenia and relative sarcopenia were independently associated with mortality (HR sarcopenia 2.20, 95% CI 1.69 to 2.86; HR relative sarcopenia 1.60, 95% CI 1.31 to 1.96). The corresponding population attributable risks were 5.2% (95% CI 3.4% to 6.4%) and 8.4% (95% CI 4.8% to 11.2%), respectively. Relative sarcopenia remained significantly associated with mortality (HR 1.32, 95% CI 1.08 to 1.61) when limited to the subset who did not meet the criteria for sarcopenia. The risk of mortality associated with relative sarcopenia was attenuated among persons with higher FMI (P for interaction <0.01) and was not affected by CKD status for either sarcopenia or relative sarcopenia.
conclusionsSarcopenia and relative sarcopenia are significantly associated with mortality regardless of CKD status. Relative sarcopenia is nearly three-fold more prevalent amplifying its associated mortality risk at the population level. The association between relative sarcopenia and mortality is attenuated in persons with higher FMI.
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Registered trials
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