ArticleJournal of veterinary internal medicine2019
Association of chronic enteropathy activity index, blood urea concentration, and risk of death in dogs with protein-losing enteropathy.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs.Journal of veterinary internal medicine · 2026Pooled it
- Clinical management and outcomes for 51 Pugs reportedly diagnosed with protein-losing enteropathy using VetCompass primary care veterinary data.The Journal of small animal practice · 2026Article
- Chronic Enteropathy and Vitamins in Dogs.Animals : an open access journal from MDPI · 2025Review
- Article
- Incidence of relapse of inflammatory protein-losing enteropathy in dogs and associated risk factors.Journal of veterinary internal medicine · 2022Article
- A Preliminary Study of Modulen IBD Liquid Diet in Hospitalized Dogs with Protein-Losing Enteropathy.Animals : an open access journal from MDPI · 2022Article
- 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Immunosuppressant-Responsive Enteropathy and Non-Responsive Enteropathy in Dogs: Prognostic Factors, Short- and Long-Term Follow Up.Animals : an open access journal from MDPI · 2021Article
- The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy.Journal of veterinary internal medicine · 2021Article
- Clinical characteristics of dogs with food-responsive protein-losing enteropathy.Journal of veterinary internal medicine · 2020Article
- Association of chronic enteropathy activity index, blood urea concentration, and risk of death in dogs with protein-losing enteropathy.Journal of veterinary internal medicine · 2019Article
- A Retrospective Evaluation of Serum Symmetric Dimethylarginine Concentration in Dogs With Protein-Losing Enteropathy.Journal of veterinary internal medicineArticle
- In-hospital mortality in dogs with protein-losing enteropathy and associated risk factors.Journal of veterinary internal medicineArticle
- An undernutrition screening score for dogs with protein-losing enteropathy: A prospective multicenter study.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition is associated with increased risk of premature death in humans with inflammatory bowel disease. HYPOTHESIS/
objectiveTo determine if historical, clinical, and laboratory markers of malnutrition in dogs at the time of histologic diagnosis of protein-losing enteropathy (PLE) caused by chronic enteropathy (CE) or lymphangiectasia are associated with increased risk of death. ANIMALS: Seventy-one client-owned dogs diagnosed with PLE.
methodsThe medical records were retrospectively searched for cases of PLE, diagnosed with CE or lymphangiectasia on the basis of histopathology of intestinal biopsies at a referral hospital. For each case, various variables at the time of diagnostic investigation were recorded and follow-up obtained by telephone contact with the referring veterinarian.
resultsA multivariable cox model indicated that canine chronic enteropathy activity index (CCEAI) and blood urea concentration were significantly associated with death (P values <.01). For each unit increase in CCEAI, the hazard of death increased by 22.9% (confidence interval [CI]: 6.9%-41.2%). Dogs with a CCEAI of ≤8 and dogs with urea ≤7 mmol/L survived 256 days longer (P = .001, CI: 106.7-405.4 days) and 279 days longer (P = .009, CI: 70.0-488.7 days) than those with a CCEAI of >8 and urea >7 mmol/L on average, respectively, when followed up for 647 days. CONCLUSIONS AND CLINICAL IMPORTANCE: Increased CCEAI and blood urea concentration at the time of diagnosis might be predictive of death in dogs with PLE caused by CE or lymphangiectasia.
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