Evidence map›Paper›PMID 30784022›Full record

ArticleDrug delivery and translational research2019

Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

Isaac M Adjei, Hao Yang, Glendon Plumton, Lorena Maldonado-Camargo, Jon Dobson, Carlos Rinaldi, Huabei Jiang, Blanka Sharma

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  3. ACS nano · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Isaac M AdjeiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Hao YangJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Glendon PlumtonJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Lorena Maldonado-CamargoDepartment of Chemical Engineering, University of Florida, Gainesville, FL, 32611, USA.
Jon DobsonJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Carlos RinaldiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Huabei JiangJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.
Blanka SharmaJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA. blanka.sharma@bme.ufl.edu.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies that control the differentiation of mesenchymal stem cells (MSC) and enable image-guided cell implantation and longitudinal monitoring could advance MSC-based therapies for bone defects and injuries. Here we demonstrate a multifunctional nanoparticle system that delivers resveratrol (RESV) intracellularly to improve osteogenesis and enables photoacoustic imaging of MSCs. RESV-loaded nanoparticles (RESV-NPs), formulated from poly (lactic-co-glycolic) acid and iron oxide, enhanced the stability of RESV by 18-fold and served as photoacoustic tomography (PAT) contrast for MSCs. Pre-loading MSCs with RESV-NP upregulated RUNX2 expression with a resultant increase in mineralization by 27% and 45% compared to supplementation with RESV-NP and free RESV, respectively, in 2-dimensional cultures. When grown in polyethylene glycol-based hydrogels, MSCs pre-loaded with RESV-NPs increased the overall level and homogeneity of mineralization compared to those supplemented with free RESV or RESV-NP. The PAT detected RESV-NP-loaded MSCs with a resolution of 1500 cells/μL, which ensured imaging of MSCs upon encapsulation in a PEG-based hydrogel and implantation within the rodent cranium. Significantly, RESV-NP-loaded MSCs in hydrogels did not show PAT signal dilution over time or a reduction in signal upon osteogenic differentiation. This multifunctional NP platform has the potential to advance translation of stem cell-based therapies, by improving stem cell function and consistency via intracellular drug delivery, and enabling the use of a promising emerging technology to monitor cells in a clinically relevant manner.

Indexed as

Drug Delivery SystemsPhotoacoustic TechniquesAnimalsCell LineFerric CompoundsHumansMagnetic Resonance ImagingMesenchymal Stem CellsMultifunctional NanoparticlesOsteogenesisRatsResveratrolFerric Compoundsferric oxideResveratrolMesenchymal stem cellsOsteogenesisPhotoacoustic imagingResveratrol

Identifiers

PMID30784022
OpenAlexW2915195762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.