ReviewJapanese journal of ophthalmology2019
Tear-film-oriented diagnosis for dry eye.
Review in Japanese journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 85 citations in OpenAlex.
- Piezo1 Activation by Shear Stress Induces Corneal Epithelial Homeostasis Disruption.Investigative ophthalmology & visual science · 2026Article
- Insights into Tear Viscosity: A Study of 240 Volunteers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Corneal epithelial thickness profiles in dry eye patients with or without primary Sjögren's syndrome.BMC ophthalmology · 2026Article
- Correlation analysis between ocular surface parameters and corneal higher-order aberrations in dry eye disease: a cross-sectional study.BMC ophthalmology · 2026Article
- Grading Scales of Conjunctival Inflammation.Diagnostics (Basel, Switzerland) · 2025Review
- Symptom-based stratification of heterogeneous symptoms of dry eye disease in patients with Sjögren's syndrome.Eye (London, England) · 2025Article
- Optimizing Diagnosis and Management of Dry Eye Disease: A Practical Framework for Hong Kong.Ophthalmology and therapy · 2025Article
- Characteristics of dry eye associated with autoimmune diseases.Japanese journal of ophthalmology · 2025Article
- Changes in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction complicated with obstructed meibomian gland dysfunction.BMC ophthalmology · 2025Article
- Tear film thickness and stability following femtosecond-assisted laserFrontiers in medicine · 2025Article
- Study on the relationship between lid-parallel conjunctival folds and symptoms and signs of dry eye disease.Frontiers in medicine · 2025Article
- Investigating Mask-Associated Dry Eye and Contributing Factors in Healthcare Providers.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- GLP-1R Agonists Improve Ocular Surface Parameters in Type 2 Diabetes Mellitus.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Electroacupuncture improves scopolamine hydrobromide induced dry eye in mice via inhibiting ocular surface inflammation and regulating the HMGB1-related signaling pathways.Frontiers in medicine · 2025Article
- Efficacy of povidone and propylene glycol-based artificial tears in the treatment of dry eye disease.Arquivos brasileiros de oftalmologia · 2025Article
- Diagnostic Performance of Visionix VX120+ Platform for Dry Eye Screening.Diagnostics (Basel, Switzerland) · 2024Article
- Management of Dry Eye Disease for Intraocular Lens Power Calculation in Cataract Surgery: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Appropriateness of Questionnaires for the Diagnosis and Monitoring Treatment of Dry Eye Disease.Journal of clinical medicine · 2024Article
- Dry Eye Disease: An Update on Changing Perspectives on Causes, Diagnosis, and Management.Cureus · 2024Review
- Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction.International ophthalmology · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured via cooperation between the ocular surface components including constituents of the TF and ocular surface epithelium. Thus, when those components are insufficient or impaired, the TF breakup that initiates dry eye occurs. Recently, new, commercially available eye drops have appeared in Japan that enable TF stabilization via targeted supplementation of deficient ocular surface components. Hence, a new layer-by-layer diagnosis and treatment concept for dry eye, termed tear-film-oriented diagnosis and tear-film-oriented therapy (TFOD and TFOT, respectively), have emerged and become widely accepted in Asian countries and beyond. TFOD is a diagnostic method for dry eye based on the TF dynamics and breakup patterns (BUPs), through which dry-eye subtypes, including aqueous-deficient dry eye, decreased-wettability dry eye, and increased-evaporation dry eye, are diagnosed. BUPs and/or each diagnosed dry-eye subtype can, in a layer-by-layer fashion, reveal the insufficient ocular surface components responsible for the TF breakup. Using these data, the optimal topical TFOT to treat dry eye can be proposed by addressing the TF breakup via the supplementation of the insufficient components. In Japan, TF breakup is now regarded as a visible core mechanism of dry eye, and abnormal breakup time (ie, ≤ 5 seconds) and symptoms are currently considered part of the diagnostic criteria for dry eye. In this review, the importance of TF instability as a core manifestation of dry eye, the molecular mechanism of TF breakup, the concept of TFOD, and the methods for implementing TFOD for TFOT are introduced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.