Evidence map›Paper›PMID 30783922›Full record

ArticleNatural products and bioprospecting2019

Bioactivity-Guided Isolation of Totarane-Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3-Deoxy-2α-hydroxynagilactone E.

P Annécie Benatrehina, Wei-Lun Chen, Austin A Czarnecki, Steven Kurina, Hee-Byung Chai, Daniel D Lantvit, Tran N Ninh, Xiaoli Zhang, Djaja D Soejarto, Joanna E Burdette and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

P Annécie BenatrehinaDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University, College of Pharmacy, Columbus, OH, USA.
Wei-Lun ChenCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Austin A CzarneckiCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Steven KurinaCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Hee-Byung ChaiDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University, College of Pharmacy, Columbus, OH, USA.
Daniel D LantvitCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Tran N NinhInstitute of Ecology and Biological Resources, Vietnam Academy of Science and Technology Hanoi, Hanoi, Vietnam.
Xiaoli ZhangCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Djaja D SoejartoCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Joanna E BurdetteCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University, College of Pharmacy, Columbus, OH, USA.
L Harinantenaina RakotondraibeDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University, College of Pharmacy, Columbus, OH, USA. rakotondraibe.1@osu.edu.ORCID http://orcid.org/0000-0003-2166-4992

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
National Cancer Institute 5P01 CA125066-10NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Bioactivity-guided phytochemical investigation of Podocarpus neriifolius D. Don. (Podocarpaceae) has led to the isolation of one new (2) and three known (1, 3, and 4) B-type podolactones, along with three totarane-type diterpenes (5-7). Their structures were determined by interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry (HRESIMS) and 1D and 2D NMR data, and comparison with the values reported in the literature. The structure of compound 1, previously identified as 3-deoxy-2α-hydroxynagilactone E (8), was revised as its 2β-epimer, which has been reported recently as a new compound. All of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines, namely, ovarian (OVCAR3), breast (MDA-MB-231), colon (HT-29), and melanoma (MDA-MB-435), and compounds 1 and 3 were found to be cytotoxic with IC

Indexed as

3-Deoxy-2α-hydroxynagilactone EAntiproliferativeB-type podolactoneHollow fiber assayNagilactone G-2β-O-β-D-glucosidePodocarpus neriifolius

Identifiers

PMID30783922
PMCPMC6426912

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.