ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
Campylobacter culture fails to correctly detect Campylobacter in 30% of positive patient stool specimens compared to non-cultural methods.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A comparison of frequentist and Bayesian methods for meta-analysis of diagnostic test accuracy studies.Epidemiology and infection · 2026Pooled it
- A systematic review of the methodological considerations in Campylobacter burden of disease studies.PLoS neglected tropical diseases · 2025Pooled it
- Diagnostic accuracy of multiplex nucleic acid amplification tests forPathogens and global health · 2023Pooled it
- Multicentre Evaluation of Cepheid XpertMicroorganisms · 2026Article
- Prevalence, species diversity, and antimicrobial resistance profiles ofMicrobiology spectrum · 2026Article
- Stool antigen-based enzyme immunoassays: performance evaluations and automation.Journal of clinical microbiology · 2026Article
- Diagnostic performance of the QIAstat-Dx gastrointestinal panel compared with conventional methods in pediatric gastroenteritis.Microbiology spectrum · 2026Article
- Sources and transmission dynamics ofmedRxiv : the preprint server for health sciences · 2026Article
- Gut microbiome dysbiosis and functional alterations inGut microbes reports · 2026Article
- Optimization ofJournal of environmental engineering (New York, N.Y.) · 2025Article
- Rapid and sensitive isolation ofMicrobiology spectrum · 2025Article
- Evaluation of a rapid fluorescence immunoassay for detecting Campylobacter antigens in stool samples.Gut pathogens · 2025Article
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- Burden and epidemiology of Campylobacter species in acute enteritis cases in Burkina Faso.BMC infectious diseases · 2024Article
- Capturing clinically relevantMicrobial genomics · 2024Article
- Campylobacteriosis and Control Strategies againstJournal of microbiology and biotechnology · 2024Review
- Multicenter evaluation of BioCode GPP for syndromic molecular detection of gastrointestinal pathogens from stool specimens.Journal of clinical microbiology · 2024Article
- Bacteria Living in Biofilms in Fluids: Could Chemical Antibiofilm Pretreatment of Culture Represent a Paradigm Shift in Diagnostics?Microorganisms · 2024Review
- The effect of changing diagnostic method from culture to PCR on the number of episodes of human campylobacteriosis in Denmark: a retrospective study (2015-2022).Microbiology spectrum · 2024Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Campylobacter diagnosis is hampered because many laboratories continue to use traditional stool culture, which is slow and suffers false-negative results. This large multi-site study used a composite reference method consisting of a new FDA-cleared immunoassay and four molecular techniques to compare to culture. Prospectively collected patient fecal specimens (1552) were first preliminarily categorized as positive or negative by traditional culture. All specimens were also tested by EIA, and any EIA-positive or culture-discrepant results were further characterized by 16S rRNA qPCR, eight species-specific PCR assays, bidirectional sequencing, and an FDA-cleared multiplex PCR panel. The five non-culture methods showed complete agreement on all positive and discrepant specimens which were then assigned as true-positive or true-negative specimens. Among 47 true-positive specimens, culture incorrectly identified 13 (28%) as negative, and 1 true-negative specimen as positive, for a sensitivity of 72.3%. Unexpectedly, among the true-positive specimens, 4 (8%) were the pathogenic species C. upsaliensis. Culture had a 30% false result rate compared to immunoassay and molecular methods. More accurate results lead to better diagnosis and treatment of suspected campylobacteriosis.
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