ArticleAnnals of biomedical engineering2019
Non-Destructive Reflectance Mapping of Collagen Fiber Alignment in Heart Valve Leaflets.
Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Extracellular matrix repair and organization of chronic infected diabetic wounds treated with methacrylated chitosan-based hydrogels.Acta biomaterialia · 2025Article
- Full-Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging.Journal of biophotonics · 2025Article
- HETEROGENEOUS PERIDYNAMIC NEURAL OPERATORS: DISCOVER BIOTISSUE CONSTITUTIVE LAW AND MICROSTRUCTURE FROM DIGITAL IMAGE CORRELATION MEASUREMENTS.Foundations of data science (Springfield, Mo.) · 2025Article
- Elastin-producing valve interstitial cells stretch our understanding of cardiac valve remodeling.Nature cardiovascular research · 2024Article
- Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.Acta biomaterialia · 2022Article
- Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications.Applied sciences (Basel, Switzerland) · 2022Article
- Simultaneous Wide-Field Planar Strain-Fiber Orientation Distribution Measurement Using Polarized Spatial Domain Imaging.Annals of biomedical engineering · 2022Article
- Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps.Journal of the mechanical behavior of biomedical materials · 2022Article
- Simulating the time evolving geometry, mechanical properties, and fibrous structure of bioprosthetic heart valve leaflets under cyclic loading.Journal of the mechanical behavior of biomedical materials · 2021Article
- Quantifying optical anisotropy in soft tissue membranes using Mueller matrix imaging.Journal of biomedical optics · 2021Article
- Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging.Journal of biomedical optics · 2021Article
- Isogeometric finite element-based simulation of the aortic heart valve: Integration of neural network structural material model and structural tensor fiber architecture representations.International journal for numerical methods in biomedical engineering · 2021Article
- Instant polarized light microscopy for imaging collagen microarchitecture and dynamics.Journal of biophotonics · 2021Article
- Biology and Biomechanics of the Heart Valve Extracellular Matrix.Journal of cardiovascular development and disease · 2020Review
- A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets.Bioengineering (Basel, Switzerland) · 2020Article
- Mechanics of Porcine Heart Valves' Strut Chordae Tendineae Investigated as a Leaflet-Chordae-Papillary Muscle Entity.Annals of biomedical engineering · 2020Article
- Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review.Bioengineering (Basel, Switzerland) · 2020Review
- Load-dependent collagen fiber architecture data of representative bovine tendon and mitral valve anterior leaflet tissues as quantified by an integrated opto-mechanical system.Data in brief · 2020Article
- Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture in soft collagenous tissues.Acta biomaterialia · 2020Article
- An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Collagen fibers are the primary structural elements that define many soft-tissue structure and mechanical function relationships, so that quantification of collagen organization is essential to many disciplines. Current tissue-level collagen fiber imaging techniques remain limited in their ability to quantify fiber organization at macroscopic spatial scales and multiple time points, especially in a non-contacting manner, requiring no modifications to the tissue, and in near real-time. Our group has previously developed polarized spatial frequency domain imaging (pSFDI), a reflectance imaging technique that rapidly and non-destructively quantifies planar collagen fiber orientation in superficial layers of soft tissues over large fields-of-view. In this current work, we extend the light scattering models and image processing techniques to extract a critical measure of the degree of collagen fiber alignment, the normalized orientation index (NOI), directly from pSFDI data. Electrospun fiber samples with architectures similar to many collagenous soft tissues and known NOI were used for validation. An inverse model was then used to extract NOI from pSFDI measurements of aortic heart valve leaflets and clearly demonstrated changes in degree of fiber alignment between opposing sides of the sample. These results show that our model was capable of extracting absolute measures of degree of fiber alignment in superficial layers of heart valve leaflets with only general a priori knowledge of fiber properties, providing a novel approach to rapid, non-destructive study of microstructure in heart valve leaflets using a reflectance geometry.
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Registered trials
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