Evidence map›Paper›PMID 30783789›Full record

ArticleEuropean radiology2019

Inter-platform reproducibility of ultrasonic attenuation and backscatter coefficients in assessing NAFLD.

Aiguo Han, Yingzhen N Zhang, Andrew S Boehringer, Michael P Andre, John W Erdman, Rohit Loomba, Claude B Sirlin, William D O'Brien

Abstract read
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In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Imaging Evaluation for Steatotic Liver Disease.Korean journal of radiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aiguo HanBioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 North Wright Street, Urbana, IL, 61801, USA. han51@illinois.edu.ORCID http://orcid.org/0000-0001-7606-9221
Yingzhen N ZhangLiver Imaging Group, Department of Radiology, University of California, San Diego, 9452 Medical Center Drive, La Jolla, CA, 92037, USA.
Andrew S BoehringerLiver Imaging Group, Department of Radiology, University of California, San Diego, 9452 Medical Center Drive, La Jolla, CA, 92037, USA.
Michael P AndreDepartment of Radiology, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
John W ErdmanDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 905 South Goodwin Avenue, Urbana, IL, 61801, USA.
Rohit LoombaNAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego, 9452 Medical Center Drive, La Jolla, CA, 92037, USA.
William D O'BrienBioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 North Wright Street, Urbana, IL, 61801, USA.

Funding

QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
National Institute of Diabetes and Digestive and Kidney Diseases R01 DK106419National Institute of Diabetes and Digestive and Kidney Diseases R01DK106419NIDDK NIH HHS R01 DK106419Siemens Healthineers USA C00214530
6 · The paper itself

Abstract

objectivesTo assess inter-platform reproducibility of ultrasonic attenuation coefficient (AC) and backscatter coefficient (BSC) estimates in adults with known/suspected nonalcoholic fatty liver disease (NAFLD).

methodsThis HIPAA-compliant prospective study was approved by an institutional review board; informed consent was obtained. Participants with known/suspected NAFLD were recruited and underwent same-day liver examinations with clinical ultrasound scanner platforms from two manufacturers. Each participant was scanned by the same trained sonographer who performed multiple data acquisitions in the right liver lobe using a lateral intercostal approach. Each data acquisition recorded a B-mode image and the underlying radio frequency (RF) data. AC and BSC were calculated using the reference phantom method. Inter-platform reproducibility was evaluated for AC and log-transformed BSC (logBSC = 10log

resultsSixty-four participants were enrolled. Mean AC values measured using the two platforms were 0.90 ± 0.13 and 0.94 ± 0.15 dB/cm/MHz while mean logBSC values were - 30.6 ± 5.0 and - 27.9 ± 5.6 dB, respectively. Inter-platform ICC was 0.77 for AC and 0.70 for log-transformed BSC in terms of absolute agreement. Pearson's correlation coefficient was 0.81 for AC and 0.80 for logBSC. Ninety-five percent LOAs were - 0.21 to 0.13 dB/cm/MHz for AC, and - 9.48 to 3.98 dB for logBSC. The wCV was 7% for AC.

conclusionsHepatic AC and BSC are reproducible across two different ultrasound platforms in adults with known or suspected NAFLD. KEY POINTS: • Ultrasonic attenuation coefficient and backscatter coefficient are reproducible between two different ultrasound platforms in adults with NAFLD. • This inter-platform reproducibility may qualify quantitative ultrasound biomarkers for generalized clinical application in patients with suspected/known NAFLD.

Indexed as

AdultAgedFemaleHumansImage Interpretation, Computer-AssistedLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseProspective StudiesReproducibility of ResultsUltrasonographyNonalcoholic fatty liver diseasePhantoms, imagingProspective studiesReproducibility of resultsUltrasonography

Identifiers

PMID30783789
PMCPMC6684824

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.