ReviewCardiovascular and interventional radiology2019
Transarterial (Chemo-)Embolization and Lipiodolization for Hepatic Haemangioma.
Review in Cardiovascular and interventional radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- To Systematically Evaluate and Analyze the Efficacy and Safety of Transcatheter Arterial Chemoembolization (TACE) in the Treatment of Primary Liver Cancer.Journal of healthcare engineering · 2022Pooled it
- Management and Clinical Outcomes of Liver Hemangiomas: A Retrospective Comparative Study of Transcatheter Arterial Embolization and Surgery.Medicina (Kaunas, Lithuania) · 2026Article
- Safety and feasibility of laparoscopic resection for giant hepatic hemangiomas: a retrospective cohort study.BMC surgery · 2026Article
- Successful long-term results (> 5 years) of superselective transarterial chemoembolization in symptomatic/enlarging liver hemangiomas: a paradigm shift at a hepatopancreatobiliary surgery unit.Frontiers in medicine · 2026Article
- Clinical outcomes of combined transarterial chemoembolization and microwave ablation for hepatic hemangiomas: a comparative analysis of large versus. giant tumors.BMC gastroenterology · 2025Article
- Efficacy and safety of transcatheter arterial chemoembolization combined with microwave ablation for hepatic hemangiomas (> 5 cm).World journal of gastroenterology · 2025Article
- Transarterial chemoembolization with bleomycin and lipiodol: a novel treatment for giant hepatic haemangiomas.Polish journal of radiology · 2025Article
- Imaging features and management of focal liver lesions.World journal of radiology · 2024Review
- Hepatic Hemangioma: Review of Imaging and Therapeutic Strategies.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Development of a set of patient reported outcome measures for patients with benign liver tumours and cysts: patient focus groups and systematic review.Journal of patient-reported outcomes · 2022Article
- Medium and Long-Term Outcome of Superselective Transcatheter Arterial Embolization with Lipiodol-Bleomycin Emulsion for Giant Hepatic Hemangiomas: Results in 241 Patients.Journal of clinical medicine · 2022Article
- Digital Staging of Hepatic Hemangiomas Reveals Spatial Heterogeneity in Endothelial Cell Composition and Vascular Senescence.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Ultrasound-guided percutaneous sclerotherapy versus surgical resection in the treatment of large hepatic hemangiomas: a retrospective study.BMC surgery · 2022Article
- Therapeutic Evaluation and Management Strategy of Transarterial Embolization for Giant Liver Hemangiomas Exceeding 10 cm in Diameter.Cardiovascular and interventional radiology · 2021Article
- The Two-Step Treatment for Giant Hepatic Hemangiomas.Journal of clinical medicine · 2021Article
- Scoping review of clinical practice guidelines on the management of benign liver tumours.BMJ open gastroenterology · 2021Article
- Endovascular treatment of a rare case of haemobilia caused by both pseudoaneurysm and a giant hepatic haemangioma.Radiology case reports · 2021Article
- Trans-Arterial Embolization for Liver Hemangiomas: It's a New Dawn; It's a New Day; It's a New Life?Cardiovascular and interventional radiology · 2021Article
- Extended liver resection including hypertrophy concept with portal venous embolisation for giant haemangioma. Too much surgery?Annals of hepato-biliary-pancreatic surgery · 2020Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundTransarterial (chemo-)embolization/lipiodolization (TAE/TAL) might be an attractive minimally invasive alternative to surgery in the treatment of symptomatic hepatic haemangioma. This review assesses the efficacy and safety of TAE/TAL as primary treatment for symptomatic hepatic haemangioma.
methodsA systematic search of the literature was performed by two reviewers following the PRISMA guidelines. Cohort studies and case reports were identified; outcomes of cohort studies were reported. The primary efficacy outcome was tumour size before and after TAE/TAL. Improvement of symptoms and quality of life (QoL) were secondary outcomes; the primary safety outcome was complications. The Downs and Black statement was used for quality assessment.
resultsEighteen cohort studies were identified, including 1284 patients. TAE/TAL led to a decrease in tumour size in 1100/1223 (89.9%) patients and to improvement or disappearance of symptoms in 1080/1096 (98.5%) patients. A significant decrease in tumour size from 9.79 ± 0.79 cm to 4.00 ± 1.36 cm (p < 0.001) was shown. Grade 3 complications occurred in 37/1284 (2.9%) patients. Surgical treatment was necessary in 35/1284 (2.7%) of patients.
conclusionTAE/TAL appears to be a promising and safe treatment to decrease tumour size of hepatic haemangioma. The technique might also provide partial relief of symptoms, although no randomized clinical trials or prospective studies using validated QoL questionnaires are available. TAE/TAL may be considered as a viable alternative to resection.
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