ArticleeNeuro
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.
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17 citing papers in PubMed, 42 citations in OpenAlex.
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- EEG focal delta slowing in focal epilepsy - A didactic review.Clinical neurophysiology practice · 2025Review
- Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.medRxiv : the preprint server for health sciences · 2024Article
- Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.Epilepsia · 2024Article
- Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.Brain communications · 2024Article
- Wake slow waves in focal human epilepsy impact network activity and cognition.Nature communications · 2023Article
- Putative cause of seizure-induced cognitive alterations: The oscillatory reconfiguration of seizure network.Frontiers in neuroscience · 2023Article
- Asymmetry of sleep electrophysiological markers in patients with focal epilepsy.Brain communications · 2023Article
- Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.Neurobiology of disease · 2022Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?Epilepsia open · 2022Review
- Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation.Acta neuropathologica communications · 2022Article
- Graph theoretical measures of fast ripples support the epileptic network hypothesis.Brain communications · 2022Article
- Article
- Rodent EEG: Expanding the Spectrum of Analysis.Epilepsy currents · 2020Article
- The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy.Frontiers in neurology · 2019Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase-amplitude coupling of the epileptic discharges over a slow oscillation at 3-5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
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