Evidence map›Paper›PMID 30783611›Full record

ArticleeNeuro

Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA).

Katheryn A Q Cousins, Sharon Ash, Christopher A Olm, Murray Grossman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Automatic classification of AD pathology in FTD phenotypes using natural speech.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  4. Article
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  6. Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Automated analysis of lexical features in frontotemporal degeneration.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
  12. Lexical and Acoustic Characteristics of Young and Older Healthy Adults.Journal of speech, language, and hearing research : JSLHR · 2021
    Article
  13. Article
  14. Article
  15. Automated analysis of lexical features in Frontotemporal Degeneration.medRxiv : the preprint server for health sciences · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Katheryn A Q CousinsDepartment of Neurology and Penn Frontotemporal Degeneration Center.
Sharon AshDepartment of Neurology and Penn Frontotemporal Degeneration Center.
Christopher A OlmDepartment of Neurology and Penn Frontotemporal Degeneration Center.
Murray GrossmanDepartment of Neurology and Penn Frontotemporal Degeneration Center.ORCID 0000-0002-7447-6218
California University of Pennsylvania · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
Semantic Memory and Language Learning in Alzheimer's Disease and Semantic DementiR01DC013063 · NIDCD · TEMPLE UNIV OF THE COMMONWEALTH · PI James Joseph Reilly · 2014 to 2026
$6.8M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
NIA NIH HHS P01 AG017586NIA NIH HHS U01 AG052943NIDCD NIH HHS R01 DC013063
6 · The paper itself

Abstract

This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral temporal lobe. It is unknown how disease spread and duration affect the magnitude of the concreteness impairment in svPPA. We evaluate longitudinal spoken production of concrete nouns in svPPA, and relate this to changes in longitudinal MRI measures of gray matter (GM). Noun concreteness in svPPA is compared to that of behavioral variant frontotemporal dementia (bvFTD) patients, who typically demonstrate highly concrete speech. We elicited naturalistic speech samples at two time points (time 1 and time 2) in patients with svPPA (

Indexed as

SemanticsSpeechAgedAphasia, Primary ProgressiveAtrophyBrainFemaleGray MatterHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle Agedconcretenessfrontotemporal dementialongitudinalsemantic memorysemantic variant primary progressive aphasiaventral temporal lobe

Identifiers

PMID30783611
PMCPMC6377408
OpenAlexW2906215493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.