Evidence map›Paper›PMID 30783376›Full record

SynthesisWorld journal of gastroenterology2019

Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis.

Dalma Dobszai, Péter Mátrai, Zoltán Gyöngyi, Dezső Csupor, Judit Bajor, Bálint Erőss, Alexandra Mikó, Lajos Szakó, Ágnes Meczker, Roland Hágendorn and 4 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dalma DobszaiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Péter MátraiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Zoltán GyöngyiDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Dezső CsuporDepartment of Pharmacognosy, University of Szeged, Szeged 6720, Hungary.
Judit BajorDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs 7624, Hungary.
Bálint ErőssInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Alexandra MikóInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Lajos SzakóInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Ágnes MeczkerInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Roland HágendornDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs 7624, Hungary.
Katalin MártaInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Andrea SzentesiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs 7624, Hungary.
Hungarian Pancreatic Study Group
University of Pecs · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis (AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index (BMI) affects the outcome of the disease.

aimTo quantify the association between subgroups of BMI and the severity and mortality of AP.

methodsA meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols. Three databases (PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. English-language studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios (OR) and mean differences (MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.

resultsA total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity; however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI (OR = 2.87, 95%CI: 1.90-4.35,

conclusionOur findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP.

Indexed as

Body Mass IndexSeverity of Illness IndexAcute DiseaseHumansObesityOdds RatioPancreatitisRisk FactorsThinnessAcute pancreatitisBody-mass indexMeta-analysisMortalityObesityPrognosticSeverity

Identifiers

PMID30783376
PMCPMC6378543
OpenAlexW2911984244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.