Evidence map›Paper›PMID 30783264›Full record

ArticleNature cell biology2019

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu and 11 more

Abstract readPublished Erratum
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Pengda LiuDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Wenjian GanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Hiroyuki InuzukaDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Adam S LazorchakDepartment of Immunobiology and The Vascular Biology and Therapeutics Program, Yale Medical School, New Haven, Connecticut, 06520, USA.
Daming GaoDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Omotooke ArojoDepartment of Immunobiology and The Vascular Biology and Therapeutics Program, Yale Medical School, New Haven, Connecticut, 06520, USA.
Dou LiuDepartment of Immunobiology and The Vascular Biology and Therapeutics Program, Yale Medical School, New Haven, Connecticut, 06520, USA.
Lixin WanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Bo ZhaiDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Yonghao YuDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Min YuanDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Byeong Mo KimDivision of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA.
Shavali ShaikDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Suchithra MenonDepartment of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, 02115, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Tae Ho LeeDivision of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA.
John M AsaraDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA.
Brendan D ManningDepartment of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, 02115, USA.
John BlenisDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Bing SuDepartment of Immunobiology and The Vascular Biology and Therapeutics Program, Yale Medical School, New Haven, Connecticut, 06520, USA.
Wenyi WeiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA. wwei2@bidmc.harvard.edu.

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
NCI NIH HHS P01 CA120964
6 · The paper itself

Abstract

In the version of this Article originally published, the labels for Rictor and mTOR in the whole cell lysate (WCL) blots were swapped in Fig. 3b and the mTOR blot was placed upside down. Unprocessed blots of mTOR were also missing from Supplementary Fig. 9. The corrected Figs are shown below. In addition, control blots for the mTOR antibody (Cell Signalling Technology #2972) were also missing. These are now provided below, as Fig. 9, and show that the lower band is likely non-specific.

Identifiers

PMID30783264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.