Trial reportScientific reports2019
A New Stress Test for Knee Joint Cartilage.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ultrasound-based assessment of talar cartilage in individuals with chronic ankle instability: a systematic review.Clinical rheumatology · 2026Pooled it
- Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- Walking speed and sound limb loading are related to femoral cartilage thickness but not cartilage deformation in those with traumatic lower-limb amputation.Osteoarthritis and cartilage open · 2026Article
- Associations between habitual walking speed and in vivo tibial cartilage strain in individuals with anterior cruciate ligament reconstruction.Osteoarthritis imaging · 2026Article
- An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.Journal of nanobiotechnology · 2026Article
- A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.Journal of biomechanics · 2025Article
- Exercise-Induced Changes in Knee Cartilage In Vivo: Comparing MRI Sequences.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Engineering Anisotropic Mechanical Properties in Large-Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement.Advanced healthcare materials · 2025Article
- Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.Osteoarthritis and cartilage open · 2025Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- A comparison of three methods for establishing an ACL reference length in vivo.Journal of biomechanics · 2024Article
- Morphologic Response in Femoral Cartilage During and After 40-Minute Treadmill Running.Journal of athletic training · 2024Article
- RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.Journal of orthopaedic translation · 2024Article
- [Role of Piezo mechanosensitive ion channels in the osteoarticular system].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing.Magnetic resonance in medicine · 2023Article
- Intraoperative Acoustic Evaluation of Living Human Knee Cartilage-Comparison with Respect to Cartilage Degeneration and Aging.Cartilage · 2023Article
- Acute Repair of Meniscus Root Tear Partially Restores Joint Displacements as Measured With Magnetic Resonance Images and Loading in a Cadaveric Porcine Knee.Journal of biomechanical engineering · 2023Article
- Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery.Journal of biomechanics · 2023Article
- In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.Osteoarthritis and cartilage · 2023Article
- Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: data from the osteoarthritis initiative.Magma (New York, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cartilage metabolism-both the synthesis and breakdown of cartilage constituents and architecture-is influenced by its mechanical loading. Therefore, physical activity is often recommended to maintain cartilage health and to treat or slow the progression of osteoarthritis, a debilitating joint disease causing cartilage degeneration. However, the appropriate exercise frequency, intensity, and duration cannot be prescribed because direct in vivo evaluation of cartilage following exercise has not yet been performed. To address this gap in knowledge, we developed a cartilage stress test to measure the in vivo strain response of healthy human subjects' tibial cartilage to walking exercise. We varied both walk duration and speed in a dose-dependent manner to quantify how these variables affect cartilage strain. We found a nonlinear relationship between walk duration and in vivo compressive strain, with compressive strain initially increasing with increasing duration, then leveling off with longer durations. This work provides innovative measurements of cartilage creep behavior (which has been well-documented in vitro but not in vivo) during walking. This study showed that compressive strain increased with increasing walking speed for the speeds tested in this study (0.9-2.0 m/s). Furthermore, our data provide novel measurements of the in vivo strain response of tibial cartilage to various doses of walking as a mechanical stimulus, with maximal strains of 5.0% observed after 60 minutes of walking. These data describe physiological benchmarks for healthy articular cartilage behavior during walking and provide a much-needed baseline for studies investigating the effect of exercise on cartilage health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.