ArticleScientific reports2019
Assessing Molecular Epidemiology of Carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Klebsiella pneumoniae: an increasing threat to public health.Annals of clinical microbiology and antimicrobials · 2020Pooled it
- Characterization ofMicrobiology spectrum · 2026Article
- Genomic epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Mwanza, Tanzania.Journal of global antimicrobial resistance · 2026Article
- Antibiotic resistance profiles and genomic analysis of Klebsiella pneumoniae ST15 with mcr-1 gene isolated from mink in China.BMC veterinary research · 2026Article
- Development and validation of a custom Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) peptide database for the rapid and accurate identification of Aeromonas spp. isolated from diseased fish.BMC veterinary research · 2026Article
- Emergence and regional evolution of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST11 in China.BMC genomics · 2025Article
- In-host co-colonization and bloodstream infection by distinct classical and hypervirulent CRKP clones harboring a homologousFrontiers in cellular and infection microbiology · 2025Article
- Identification of an IncHI5-like plasmid co-harboringFrontiers in microbiology · 2025Article
- Characterization of resistance genes and replicon typing in Carbapenem-resistant Klebsiella pneumoniae strains.Annals of clinical microbiology and antimicrobials · 2024Article
- Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence.Nature communications · 2023Article
- Evaluating molecular epidemiology of carbapenem non-susceptible Klebsiella pneumoniae isolates with MLST, MALDI-TOF MS, PFGE.Annals of clinical microbiology and antimicrobials · 2023Article
- Clinical characteristics of carbapenem-resistantBMJ open · 2023Article
- Risk factors and molecular epidemiology of fecal carriage of carbapenem resistant Enterobacteriaceae in patients with liver disease.Annals of clinical microbiology and antimicrobials · 2023Article
- Molecular typing methods & resistance mechanisms of MDRAIMS microbiology · 2023Review
- Classification and prediction ofPeerJ · 2023Article
- Comparison of bloodstream and non-bloodstream infections caused by carbapenem-resistantFrontiers in medicine · 2023Article
- Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.BMC infectious diseases · 2022Article
- Differentiation ofMicroorganisms · 2022Article
- Predictors of Occurrence and 30-Day Mortality for Co-Infection of Carbapenem-ResistantFrontiers in cellular and infection microbiology · 2022Article
- Investigation of MALDI-TOF Mass Spectrometry for Assessing the Molecular Diversity ofDiagnostics (Basel, Switzerland) · 2021Article
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19 authors.
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Abstract
Carbapenem-resistant K. pneumoniae (CR-KP) posts significant public health challenge worldwide. The aim of this study is to assess clinical characteristics and molecular epidemiology of CR-KP infections with Multilocus sequence typing (MLST) and Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in Central China. A total of 71 CR-KP isolates were recovered in a teaching hospital from October 2014 to December 2015. Among all CR-KP isolates, 73.2% (52) produced K. pneumoniae carbapenemases-2 (KPC-2). Eighteen ST types were identified by MLST, among these ST types, forty-seven isolates belonged to ST11 type, which was the predominant outbreak strain in China, and most ST11 isolates produced KPC-2. Eleven mass spectrometry (MS) types were identified by MALDI-TOF MS analysis, 53.5% isolates were MS4 and MS6, which matched with ST11 in MLST analysis. CR-KP infection was associated with increased medical cost and longer hospitalization. Therefore, we found that KPC-2-producing ST11 (MS4 and MS6) CR-KP isolates were the predominant clone identified by MLST and MALDI-TOF, and CR-KP infection was associated with increased hospital costs and longer hospitalization.
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