ArticleNature communications2019
Single gold-bridged nanoprobes for identification of single point DNA mutations.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Simultaneous Nucleation-Nanowelding Generates Uniform Plasmonic Au-Au Nanojunctions in 3D-Welded Gold Nanostructures.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Optical detection of single sub-15 nm objects using elastic scattering strong coupling.Nature communications · 2025Article
- Synthesis with control of DNA nanoflowers towards biomedical applications.Materials today. Bio · 2025Review
- Development of a point-of-care-testing platform: localized surface plasmon resonance biosensor for rapid ABO/Rh blood typing.RSC advances · 2025Article
- Hot-spot empowered gold nanoparticles for theranostics in breast cancer.Theranostics · 2025Review
- Nanoplasmonic biosensors for precision medicine.Frontiers in chemistry · 2023Review
- Design of an optical nanobiosensor for detection ofIranian journal of microbiology · 2022Article
- Chitosan-Mediated Environment-Friendly Synthesis of Gold Nanoparticles with Enhanced Photonic Reactivity.Nanomaterials (Basel, Switzerland) · 2022Article
- Anisotropic CdSe Tetrapods in Vortex Flow for Removing Non-Specific Binding and Increasing Protein Capture.Sensors (Basel, Switzerland) · 2022Article
- Peroxidase-Mimicking Activity of Biogenic Gold Nanoparticles Produced fromACS applied bio materials · 2022Article
- RNA polymerization actuating nucleic acid membrane (RANAM)-based biosensing for universal RNA virus detection.Biosensors & bioelectronics · 2022Article
- Targeted design of green carbon dot-CA-125 aptamer conjugate for the fluorescence imaging of ovarian cancer cell.Cell biochemistry and biophysics · 2022Article
- Review
- DNA Nanotechnology-Enabled Fabrication of Metal Nanomorphology.Research (Washington, D.C.) · 2022Review
- MutS protein-based fiber optic particle plasmon resonance biosensor for detecting single nucleotide polymorphisms.Analytical and bioanalytical chemistry · 2021Article
- Plasmonic Biosensors for Single-Molecule Biomedical Analysis.Biosensors · 2021Review
- Gold Nanoparticles in Cancer Theranostics.Frontiers in bioengineering and biotechnology · 2021Review
- The spatial organization of trace silver atoms on a DNA template.RSC advances · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consensus ranking of protein affinity to identify point mutations has not been established. Therefore, analytical techniques that can detect subtle variations without interfering with native biomolecular interactions are required. Here we report a rapid method to identify point mutations by a single nanoparticle sensing system. DNA-directed gold crystallization forms rod-like nanoparticles with bridges based on structural design. The nanoparticles enhance Rayleigh light scattering, achieving high refractive-index sensitivity, and enable the system to monitor even a small number of protein-DNA binding events without interference. Analysis of the binding affinity can compile an atlas to distinguish the potential of various point mutations recognized by MutS protein. We use the atlas to analyze the presence and type of single point mutations in BRCA1 from samples of human breast and ovarian cancer cell lines. The strategy of synthesis-by-design of plasmonic nanoparticles for sensors enables direct identification of subtle biomolecular binding distortions and genetic alterations.
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