ArticleNature communications2019
Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Exploring single-cell biosynthetic noise and dynamics for enhanced betaxanthin production in Escherichia coli.Nature communications · 2025Article
- Quantitative phase imaging by gradient retardance optical microscopy.Scientific reports · 2024Article
- Artificial intelligence-enabled quantitative phase imaging methods for life sciences.Nature methods · 2023Review
- Video-rate Raman-based metabolic imaging by Airy light-sheet illumination and photon-sparse detection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- High-fidelity optical diffraction tomography of live organisms using iodixanol refractive index matching.Biomedical optics express · 2022Article
- Density fluctuations, homeostasis, and reproduction effects in bacteria.Communications biology · 2022Article
- Synthetic aperture interference light (SAIL) microscopy for high-throughput label-free imaging.Applied physics letters · 2021Article
- Noise suppression in stochastic genetic circuits using PID controllers.PLoS computational biology · 2021Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Multiscale Assay of Unlabeled Neurite Dynamics Using Phase Imaging with Computational Specificity.ACS sensors · 2021Article
- Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli.Nature communications · 2021Article
- Microbial metabolic noise.WIREs mechanisms of disease · 2021Review
- Article
- Integrative quantitative-phase and airy light-sheet imaging.Scientific reports · 2020Article
- Tracing metabolic flux through time and space with isotope labeling experiments.Current opinion in biotechnology · 2020Review
- Effects of substrate patterning on cellular spheroid growth and dynamics measured by gradient light interference microscopy (GLIM).Journal of biophotonics · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Optimal metabolic trade-offs between growth and productivity are key constraints in strain optimization by metabolic engineering; however, how cellular noise impacts these trade-offs and drives the emergence of subpopulations with distinct resource allocation strategies, remains largely unknown. Here, we introduce a single-cell strategy for quantifying the trade-offs between triacylglycerol production and growth in the oleaginous microorganism Yarrowia lipolytica. The strategy relies on high-throughput quantitative-phase imaging and, enabled by nanoscale secondary ion mass spectrometry analyses and dedicated image processing, allows us to image how resources are partitioned between growth and productivity. Enhanced precision over population-averaging biotechnologies and conventional microscopy demonstrates how cellular noise impacts growth and productivity differently. As such, subpopulations with distinct metabolic trade-offs emerge, with notable impacts on strain performance and robustness. By quantifying the self-degradation of cytosolic macromolecules under nutrient-limiting conditions, we discover the cell-to-cell heterogeneity in protein and fatty-acid recycling, unmasking a potential bet-hedging strategy under starvation.
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