Observational studyCerebrovascular diseases (Basel, Switzerland)2019
Reduced Hypoxic Tissue and Cognitive Improvement after Revascularization Surgery for Chronic Cerebral Ischemia.
Observational study in Cerebrovascular diseases (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 18 citations in OpenAlex.
- Regional cerebral FDG-PET metabolic patterns across severity of extracranial internal carotid artery stenosis.Neuroimage. Reports · 2026Article
- Article
- Upper extremity motor improvement after carotid endarterectomy associated with postoperative recovery in cerebral perfusion and cortical neurotransmitter receptor function.Neurosurgical review · 2025Article
- Unveiling the influence of lateralized carotid artery revascularization on cognitive function: a comparative analysis.Frontiers in neurology · 2025Article
- Impact of carotid artery revascularization on cognitive function: a study of symptomatic and asymptomatic cases.Frontiers in neurology · 2025Article
- Impact of Internal Carotid Stenosis Treatment on Cerebral Blood Flow Volume: A Comparative Study between Preoperative and Postoperative Values.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration.International journal of environmental research and public health · 2022Article
- Differential Cognitive Functioning and Benefit From Surgery in Patients Undergoing Coronary Artery Bypass Grafting and Carotid Endarterectomy.Frontiers in neurology · 2022Article
- Effect of Acute Normobaric Hypoxia Exposure on Executive Functions among Young Physically Active Males.Journal of clinical medicine · 2021Article
- Comparison of Subjective and Objective Assessments on Improvement in Gait Function after Carotid Endarterectomy.Sensors (Basel, Switzerland) · 2020Article
- Beneficial Effect of Carotid Artery Stenting on Cerebral Hemodynamic Impairment and Cognitive Function.Neurologia medico-chirurgica · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundHypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia.
objectivesWe used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement.
methodEighteen patients with abnormally reduced cerebral blood flow (CBF) in the affected cerebral hemispheres on preoperative brain perfusion SPECT -underwent CEA. They underwent 18F-FRP170 PET and neuropsychological tests preoperatively and 6 months postoperatively. Brain perfusion SPECT was also performed 6 months postoperatively. Regions of interest were placed in the bilateral middle cerebral artery territories on SPECT and PET images, and the ratio of values in the affected versus contralateral hemispheres was calculated.
resultsThe CBF ratio (p = 0.0006) and 18F-FRP170 ratio (p = 0.0084) were significantly increased and reduced, respectively, after surgery compared to the corresponding ratios before surgery. The difference in the 18F-FRP170 ratio (postoperative - preoperative value) was negatively correlated with the difference in the CBF ratio (ρ = -0.695; p = 0.0009). The difference in the 18F-FRP170 ratio was significantly lower in patients with postoperative improved cognition compared to that in those without (p = 0.0007). The area under the receiver operating characteristics curve for the difference in the 18F-FRP170 ratio for detecting postoperative improved cognition was significantly greater than that for the difference in the CBF ratio (difference between areas, 0.278; p = 0.0248).
conclusionsHypoxic tissue is reduced following the restoration of cerebral perfusion with revascularization surgery in patients with severe atherosclerotic stenosis of the cervical ICA. The reduction in hypoxic tissue is associated with cognitive improvement in such patients.
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