ArticleScience signaling2019
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
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Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity.Molecular psychiatry · 2026Article
- Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy.Neurobiology of disease · 2025Article
- Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis.Frontiers in pharmacology · 2025Article
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Emerging modes of regulation of neuromodulatory G protein-coupled receptors.Trends in neurosciences · 2024Review
- Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity.The Journal of clinical investigation · 2023Article
- Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs.The Journal of cell biology · 2023Article
- Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: Relevance for novel therapeutics.Neuropharmacology · 2023Review
- SNAP25 differentially contributes to GFrontiers in cellular neuroscience · 2023Article
- Distinct mechanisms of CB1 and GABAThe Journal of physiology · 2023Article
- Synaptic Integration of Subquantal Neurotransmission by Colocalized G Protein-Coupled Receptors in Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Presynaptic mechanisms underlying GABACell reports · 2022Article
- Article
- Mice Expressing Regulators of G protein Signaling-insensitive Gαo Define Roles ofMolecular pharmacology · 2021Article
- Article
- Article
- Biased ligands at opioid receptors: Current status and future directions.Science signaling · 2021Review
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- Sexual Dimorphism in Stress-induced Hyperthermia in SNAP25Δ3 mice, a mouse model with disabled Gβγ regulation of the exocytotic fusion apparatus.The European journal of neuroscience · 2020Article
- The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.The Journal of biological chemistry · 2020Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Zack ZurawskiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-3621-5137
Analisa D Thompson GrayDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-7075-3695
Lillian J BradyDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-7851-025X
Brian PageDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-8945-568X
Emily ChurchDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-7747-3549
Nicholas A HarrisDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-5702-1342
Michael R DohnDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Yun Young YimDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-0061-6820
Karren HydeDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Douglas P MortlockDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Carrie K JonesDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-1287-9839
Danny G WinderDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Simon AlfordDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-0454-4246
Heidi E HammDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. heidi.hamm@vanderbilt.edu.ORCID 0000-0001-5437-5287
Vanderbilt University · USUniversity of Illinois Chicago · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MSex Dependent Recruitment of PKCdelta Neurons by Stress: Administrative Supplement for Noradrenergic Regulation in the BNSTR01DA042475 · NIDA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2016 to 2025
$4.0MG PROTEIN STRUCTURE/FUNCTIONR01EY010291 · NEI · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 1994 to 2010
$3.9MGPCR Regulation of insulin secretion by modulation of the release machineryR01DK109204 · NIDDK · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 2016 to 2019
$1.4MOptimization of modulators of Gbg-SNARE interactionR01MH101679 · NIMH · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, STAUFFER, SHAUN R · 2014 to 2016
$1.2MNon-canonical activating effects of alpha2a adrenergic receptor agonism in the bed nucleus of the stria terminalisF30DA042501 · NIDA · VANDERBILT UNIVERSITY · PI HARRIS, NICHOLAS ANDREW · 2016 to 2019
$144kNCI NIH HHS P30 CA068485NEI NIH HHS R01 EY010291NIDA NIH HHS F30 DA042501NIDA NIH HHS R01 DA042475NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK109204NIDDK NIH HHS U24 DK059637NIMH NIH HHS R01 MH101679
Abstract
G protein-coupled receptors (GPCRs) that couple to G
Indexed as
AnimalsCalciumExocytosisGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsMice, Inbred C57BLMice, Inbred DBAMice, KnockoutNeural InhibitionPhenotypeProtein BindingReceptors, G-Protein-CoupledSynaptic TransmissionSynaptosomal-Associated Protein 25CalciumGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsReceptors, G-Protein-CoupledSynaptosomal-Associated Protein 25
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.