Evidence map›Paper›PMID 30782996›Full record

ArticleAntimicrobial agents and chemotherapy2019

The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance

Corey Westfall, Ana Lidia Flores-Mireles, John Isaac Robinson, Aaron J L Lynch, Scott Hultgren, Jeffrey P Henderson, Petra Anne Levin

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 88 citations in OpenAlex.

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  16. Transcriptomic Changes andVeterinary sciences · 2023
    Article
  17. Article
  18. Article
  19. Effect of endocrine disruptors on bacterial virulence.Frontiers in cellular and infection microbiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Corey Westfall *Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
Ana Lidia Flores-Mireles *Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
John Isaac RobinsonDivision of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-3107-0047
Aaron J L LynchDepartment of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
Scott HultgrenDepartment of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
Jeffrey P HendersonDivision of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Petra Anne LevinDepartment of Biology, Washington University in St. Louis, St. Louis, Missouri, USA plevin@wustl.edu.
Washington University in St. Louis · USUniversity of Notre Dame · US

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
HOMEOSTATIC CONTROL OF BACTERIAL GROWTH AND CELL DIVISIONR35GM127331 · NIGMS · WASHINGTON UNIVERSITY · PI Petra Anne Levin · 2018 to 2026
$4.3M
TEMPORAL AND SPATIAL CONTROL OF B SUBTILIS CYTOKINESISR01GM064671 · NIGMS · WASHINGTON UNIVERSITY · PI LEVIN, PETRA ANNE · 2002 to 2016
$3.9M
EXPRESSION AND IRON-INDEPENDENT FUNCTIONS OF SIDEROPHORES IN URINARY TRACT INFECTR01DK099534 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2014 to 2018
$1.8M
EBPA-FIBROGEN INTERACTION IN ENTEROCOCCUS FAECALIS CAUTIR01AI108749 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2014 to 2017
$1.5M
Metabolomic Mechanisms of Nutritional Immunity in the Urinary TractR01DK111930 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2018 to 2021
$1.4M
NIAID NIH HHS R01 AI108749NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406NIDDK NIH HHS R01 DK099534NIDDK NIH HHS R01 DK111930NIGMS NIH HHS R01 GM064671NIGMS NIH HHS R35 GM127331
6 · The paper itself

Abstract

The antimicrobial triclosan is used in a wide range of consumer products ranging from toothpaste, cleansers, socks, and baby toys. A bacteriostatic inhibitor of fatty acid synthesis, triclosan is extremely stable and accumulates in the environment. Approximately 75% of adults in the United States have detectable levels of the compound in their urine, with a sizeable fraction of individuals (>10%) having urine concentrations equal to or greater than the minimal inhibitory concentration for

Indexed as

AnimalsAnti-Infective AgentsGuanosine TetraphosphateMaleMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsTriclosanUrinary Tract InfectionsAnti-Infective AgentsGuanosine TetraphosphateTriclosanantimicrobial agentsantimicrobial safetygeneticsurinary tract infection

Identifiers

PMID30782996
PMCPMC6496070
OpenAlexW2912690269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.