Evidence map›Paper›PMID 30782989›Full record

ArticleAntimicrobial agents and chemotherapy2019

Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect.

Paul G Ambrose, Brian D VanScoy, Brian M Luna, Jun Yan, Amber Ulhaq, Travis B Nielsen, Sue Rudin, Kristine Hujer, Robert A Bonomo, Luis Actis and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Paul G AmbroseInstitute for Clinical Pharmacodynamics, Schenectady, New York, USA.
Brian D VanScoyInstitute for Clinical Pharmacodynamics, Schenectady, New York, USA.
Brian M LunaDepartment of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-6718-4551
Jun YanDepartment of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Amber UlhaqDepartment of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Travis B NielsenDepartment of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Sue RudinLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Kristine HujerLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Robert A BonomoLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Luis ActisDepartments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-9644-9088
Eric SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.
Brad SpellbergDepartment of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA brad.spellberg@usc.edu.
University of Southern California · USLouis Stokes Cleveland VA Medical Center · USInstitute for Clinical Pharmacodynamics (United States) · USCase Western Reserve University · USVanderbilt University · US

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Humanized Monoclonal Antibody to Treat Acinetobacter InfectionsR42AI106375 · NIAID · BIOLOGICAL ANTI-INFECTIVE MEDICINES, LLC · PI ISLAM, KHALID · 2016 to 2018
$3.1M
Transferrin Combination Therapy to Address Antimicrobial ResistanceR01AI117211 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2016 to 2019
$2.7M
The Surface of Hospitals Intensive Environmental Load Disinfection (SHIELD) StudyR01HS025690 · AHRQ · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2017 to 2020
$1.8M
Humanized Monoclonal Antibodies to Treat Acinetobacter InfectionsR41AI106375 · NIAID · BIOLOGICAL ANTI-INFECTIVE MEDICINES, LLC · PI SPELLBERG, BRAD J · 2013 to 2014
$574k
Diabetes and Inflammation During InfectionR21AI127954 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2017 to 2018
$454k
Transferrin As a Novel Approach to Combat MucormycosisR21AI132923 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2018 to 2019
$454k
AHRQ HHS R01 HS025690NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI117211NIAID NIH HHS R01 AI130060NIAID NIH HHS R21 AI127954NIAID NIH HHS R21 AI132923NIAID NIH HHS R41 AI106375NIAID NIH HHS R42 AI106375
6 · The paper itself

Abstract

There has been renewed interest in combining traditional small-molecule antimicrobial agents with nontraditional therapies to potentiate antimicrobial effects. Apotransferrin, which decreases iron availability to microbes, is one such approach. We conducted a 48-h one-compartment

Indexed as

Anti-Bacterial AgentsApoproteinsCiprofloxacinFluoroquinolonesKlebsiellaMicrobial Sensitivity TestsTransferrinAnti-Bacterial AgentsApoproteinsapotransferrinCiprofloxacinFluoroquinolonesTransferrinantibiotic resistanceciprofloxacinfluoroquinoloneKlebsiellatransferrin

Identifiers

PMID30782989
PMCPMC6496049
OpenAlexW2916737756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.