Evidence map›Paper›PMID 30782949›Full record

ArticleBMJ open2019

Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.

Griselda de Marco, Ana Barbara Garcia-Garcia, Jose Tomas Real, Veronica Gonzalez-Albert, Laisa-Socorro Briongos-Figuero, Marta Cobos-Siles, Ana Lago-Sampedro, Arturo Corbaton, Maria Teresa Martinez-Larrad, Rafael Carmena and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Succinate dehydrogenase complex subunit C: Role in cellular physiology and disease.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  5. Article
  6. Polycystic ovary syndrome and mitochondrial dysfunction.Reproductive biology and endocrinology : RB&E · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Griselda de MarcoGenomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.
Ana Barbara Garcia-GarciaGenomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.
Jose Tomas RealCIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
Veronica Gonzalez-AlbertGenomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.
Laisa-Socorro Briongos-FigueroInternal Medicine Service, Rio Hortega University Hospital, Valladolid, Spain.
Marta Cobos-SilesInternal Medicine Service, Rio Hortega University Hospital, Valladolid, Spain.
Ana Lago-SampedroCIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
Arturo CorbatonCIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
Maria Teresa Martinez-LarradCIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
Rafael CarmenaDepartment of Medicine, University of Valencia, Valencia, Spain.
Juan Carlos Martin-EscuderoInternal Medicine Service, Rio Hortega University Hospital, Valladolid, Spain.
Gemma Rojo-MartínezCIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spain.
Felipe Javier ChavesGenomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.
INCLIVA Health Research Institute · ESHospital Universitario Río Hortega · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESInstituto de Investigación Biomédica de Málaga · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk.

designThis work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South).

settingForty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Association studies with BMI and obesity risk were performed for each population. These associations were then verified by analysis of the studied population as a whole (3731 samples).

participantsA total of 3731 Caucasian individuals: 1502 samples from HORTEGA, 988 from PIZARRA and 1241 from SEGOVIA.

resultsrs4600063 (

conclusionsSeveral polymorphisms from genes coding MRC proteins may be involved in BMI variability and could be related to the risk to become obese in the Spanish general population.

Indexed as

Polymorphism, Single NucleotideAdultAgedAllelesBody Mass IndexCross-Sectional StudiesElectron Transport Chain Complex ProteinsFemaleGenotypeHumansMaleMiddle AgedMitochondrial ProteinsObesityRisk FactorsSpainElectron Transport Chain Complex ProteinsMitochondrial Proteinsmitochondrial respiratory chainobesitysnp

Identifiers

PMID30782949
PMCPMC6377525
OpenAlexW2911308431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.