Evidence map›Paper›PMID 30782904›Full record

ArticleBMJ open2019

Effects of maternal B12 supplementation on neurophysiological outcomes in children: a study protocol for an extended follow-up from a placebo randomised control trial in Bangalore, India.

Shilpa Anand, Susan Thomas, Mahesh Jayachandra, Tinku Thomas, Tor Arne Strand, Anura V Kurpad, Christopher P Duggan, Krishnamachari Srinivasan

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00641862 (Randomized Trial of Vitamin B12 in Pregnant Indian Women), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00641862 nacompletednot on this map

Randomized Trial of Vitamin B12 in Pregnant Indian Women

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2008 to 2011Enrolled366ConditionsPregnancyArmsVitamin B12, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Shilpa AnandDivision of Mental Health and Neurosciences, St. John's Research Institute, Bangalore, Karnataka, India.
Susan ThomasDivision of Mental Health and Neurosciences, St. John's Research Institute, Bangalore, Karnataka, India.
Mahesh JayachandraDivision of Mental Health and Neurosciences, St. John's Research Institute, Bangalore, Karnataka, India.
Tinku ThomasDepartment of Biostatistics, St John's Medical College, Bangalore, Karnataka, India.
Tor Arne StrandCentre for International Health, University of Bergen, Bergen, Norway.
Anura V KurpadDivision of Nutrition, St. John's Research Institute, Bangalore, Karnataka, India.
Christopher P DugganCenter for Nutrition, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Krishnamachari SrinivasanSt John's Research Institute, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.
St. John's National Academy of Health Sciences · INBoston Children's Hospital · USSt.John's Medical College Hospital · INUniversity of Bergen · NO

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
HIV/AIDS through the eyes of young Africans: an analysis of fictional narrativesR03HD054323 · NICHD · EMORY UNIVERSITY · PI WINSKELL, S KATE · 2007 to 2008
$151k
NICHD NIH HHS R03 HD054323NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

introductionVitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Assessing neurophysiological measures using event-related potentials (ERPs) in children may provide additional information on the effect of maternal vitamin B12 supplementation on offspring brain function. The study examines the effects of oral vitamin B12 daily supplements (50 µg) to pregnant Indian women on child neurophysiological function at 72 months. METHODS AND ANALYSIS: We previously conducted a double-blind, placebo-controlled study to examine the effects of maternal vitamin B12 supplementation on cognitive outcomes in their offspring using the Bayley scales of infant development, third edition. In this extended follow-up of the same cohort of mother-child dyad, we propose to use ERP to study the long-term impact of maternal B12 supplementation on brain function in children at 72 months of age. We intend to use P300 and mismatch negativity (MMN) as measures of neurophysiological outcomes. The primary outcome of this study will be child neurophysiological measures (as measured by amplitude and latency of P300 and MMN) assessed at 72 months of age in children whose mothers received vitamin B12 compared with neurophysiological status of children whose mothers received placebo. ETHICS AND DISSEMINATION: The study was approved by the Institutional Ethical Board of St. John's Medical College and the Harvard School of Public Health Human Subjects Committee. Results obtained will be presented at national and international research meetings and published in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT00641862.

Indexed as

ChildChild, PreschoolEvent-Related Potentials, P300Evoked PotentialsFemaleFollow-Up StudiesHumansIndiaInfantInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsRandomized Controlled Trials as TopicVitamin B 12Vitamin B 12 DeficiencyVitamin B 12Vitamin B Complexbrain developmentchildrenevent related potentialsmaternal vitamin B12 supplementationneurophysiologyP300 and mismatch negativity

Identifiers

PMID30782904
PMCPMC6377540
OpenAlexW2911706488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.