Evidence map›Paper›PMID 30782901›Full record

Observational studyBMJ open2019

Temporal trends in severe morbidity and mortality associated with ectopic pregnancy requiring hospitalisation in Washington State, USA: a population-based study.

Sarka Lisonkova, Justin Tan, Qi Wen, Lobna Abdellatif, Lindsay L Richter, Sukainah Alfaraj, Paul J Yong, Mohamed A Bedaiwy

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sarka LisonkovaDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-1220-310X
Justin TanDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Qi WenDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Lobna AbdellatifDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Lindsay L RichterDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Sukainah AlfarajDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Paul J YongDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
Mohamed A BedaiwyDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CA

Funding

CIHR F17-02161
6 · The paper itself

Abstract

objectiveTo examine temporal trend in maternal mortality/severe morbidity associated with hospitalisation due to ectopic pregnancy.

designA population-based observational study. SETTING AND

participantsAll women hospitalised for ectopic pregnancy in Washington State, USA, 1987-2014 (n=20 418). The main composite outcome of severe morbidity/mortality included death, sepsis, need for transfusion, hysterectomy and systemic or organ failure, identified by diagnostic and procedure codes from hospitalisation files. Severe morbidity/mortality due to ectopic pregnancy were expressed as incidence ratios among women of reproductive age (15-64 years) and among women hospitalised for ectopic pregnancy. Comparisons were made between 1987-1991 (reference) and 2010-2014 using ratios of incidence ratios (RR) and ratio differences (RD). The Cochran-Armitage test for trend assessed statistical significance; logistic regression was used to obtain adjusted OR (AOR) and 95% CI, adjusted for demographic factors and comorbidity.

resultsHospitalisation for ectopic pregnancy declined from 0.89 to 0.16 per 1000 reproductive age women between 1987-1991 and 2010-2014 (p<0.001). Among reproductive age women, ectopic pregnancy mortality remained stable (0.03 per 100 000); and mortality/severe morbidity increased among women aged 25-34 years (p=0.022). Among women hospitalised for ectopic pregnancy, mortality increased from 0.29 to 1.65 per 1000 between 1987-1991 and 2010-2015 (p=0.06); severe morbidity/mortality increased from 3.85% to 19.63% (RR=5.10, 95% CI 4.36 to 5.98; RD=15.78 per 100 women, 95% CI 13.90 to 17.66; AOR for 1-year change was 1.08, 95% CI 1.07 to 1.08).

conclusionsHospitalisation for ectopic pregnancy declined in Washington State, USA, between 1987 and 2014; however, mortality/severe morbidity associated with ectopic pregnancy increased in female population aged 25-34 years.

Indexed as

HospitalizationAdolescentAdultBlood TransfusionFemaleHumansHysterectomyIncidenceIntensive Care UnitsLiver FailureLogistic ModelsMaternal MortalityMiddle AgedMorbidityPregnancyPregnancy Complications, Cardiovascularectopic pregnancyepidemiologyreproductive medicine

Identifiers

PMID30782901
PMCPMC6367962
OpenAlexW2913310217

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.