Evidence map›Paper›PMID 30782843›Full record

ArticleThe Journal of biological chemistry2019

Importance of a tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in

Ha An Nguyen, Eric D Hoffer, Christine M Dunham

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. tRNA therapeutics for genetic diseases.Nature reviews. Drug discovery · 2024
    Review
  13. Article
  14. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  15. Article
  16. Structural and functional characterization of TrmM in mProtein science : a publication of the Protein Society · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ha An NguyenFrom the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 and.
Eric D HofferFrom the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 and.
Christine M DunhamFrom the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 and christine.m.dunham@emory.edu.ORCID 0000-0002-8821-688X

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2M
Structural Studies of Ribosome RegulationR01GM093278 · NIGMS · EMORY UNIVERSITY · PI DUNHAM, CHRISTINE M · 2010 to 2022
$4.6M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Phase II SER-CAT Optimization: Acquisition of a next generation area detectorS10RR028976 · NCRR · UNIVERSITY OF GEORGIA · PI WANG, BI-CHENG · 2010 to 2010
$1.5M
Acquition of a microdiffractometer for SER-CATS10RR025528 · NCRR · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2009 to 2009
$414k
NCRR NIH HHS S10 RR025528NCRR NIH HHS S10 RR028976NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM093278NIH HHS S10 OD021527
6 · The paper itself

Abstract

Modification of anticodon nucleotides allows tRNAs to decode multiple codons, expanding the genetic code. Additionally, modifications located in the anticodon loop, outside the anticodon itself, stabilize tRNA–codon interactions, increasing decoding fidelity. Anticodon loop nucleotide 37 is 3′ to the anticodon and, in

Indexed as

Nucleic Acid ConformationRNA Processing, Post-TranscriptionalAnticodonCrystallography, X-RayEscherichia coliRibosomesRNA, BacterialAnticodonRNA, BacterialdecodingmRNAmRNA frame maintenanceribosomeRNA modificationstructural biologytransfer RNA (tRNA)translation

Identifiers

PMID30782843
PMCPMC6462517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.