ArticleProceedings of the National Academy of Sciences of the United States of America2019
Amyloid fibril-directed synthesis of silica core-shell nanofilaments, gels, and aerogels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 89 citations in OpenAlex.
- Engineered protein nanofibrils for chain-integrated water treatment: From source monitoring to end-point purification.Eco-Environment & Health · 2026Review
- Competition Between Liquid-Liquid Crystalline Phase Separation (LLCPS) and Liquid-Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.Bioactive materials · 2026Article
- Bioengineered silicon nanoparticles in agroecosystems: molecular mechanisms, stress tolerance, and environmental implications.Frontiers in plant science · 2026Review
- From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications.ACS applied materials & interfaces · 2025Review
- Fava Bean Protein Nanofibrils Modulate Cell Membrane Interfaces for Biomolecular Interactions as Unveiled by Atomic Force Microscopy.Foods (Basel, Switzerland) · 2024Article
- Nanoengineered Silica-Based Biomaterials for Regenerative Medicine.International journal of molecular sciences · 2024Review
- Interfacial Electrostatic Self-Assembly of Amyloid Fibrils into Multifunctional Protein Films.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Tuning Peptide-Based Hydrogels: Co-Assembly with Composites Driving the Highway to Technological Applications.International journal of molecular sciences · 2022Review
- Green Ambient-Dried Aerogels with a Facile pH-Tunable Surface Charge for Adsorption of Cationic and Anionic Contaminants with High Selectivity.Biomacromolecules · 2022Article
- Carbon Material-Based Aerogels for Gas Adsorption: Fabrication, Structure Design, Functional Tailoring, and Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Atomic Force Microscopy (AFM) on Biopolymers and Hydrogels for Biotechnological Applications-Possibilities and Limits.Polymers · 2022Review
- Amyloid-Templated Palladium Nanoparticles for Water Purification by Electroreduction.Angewandte Chemie (International ed. in English) · 2022Article
- Bio-Based and Robust Polydopamine Coated Nanocellulose/Amyloid Composite Aerogel for Fast and Wide-Spectrum Water Purification.Polymers · 2021Article
- Amyloids as Building Blocks for Macroscopic Functional Materials: Designs, Applications and Challenges.International journal of molecular sciences · 2021Review
- Recent developments in sustainably sourced protein-based biomaterials.Biochemical Society transactions · 2021Review
- From Protein Building Blocks to Functional Materials.ACS nano · 2021Review
- Microfluidics for the rapid and controlled preparation of organic nanotubes of bent-core based dendrimers.Nanoscale advances · 2021Article
- Sustaining Protein Nutrition Through Plant-Based Foods.Frontiers in nutrition · 2021Review
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid fibrils have evolved from purely pathological materials implicated in neurodegenerative diseases to efficient templates for last-generation functional materials and nanotechnologies. Due to their high intrinsic stiffness and extreme aspect ratio, amyloid fibril hydrogels can serve as ideal building blocks for material design and synthesis. Yet, in these gels, stiffness is generally not paired by toughness, and their fragile nature hinders significantly their widespread application. Here we introduce an amyloid-assisted biosilicification process, which leads to the formation of silicified nanofibrils (fibril-silica core-shell nanofilaments) with stiffness up to and beyond ∼20 GPa, approaching the Young's moduli of many metal alloys and inorganic materials. The silica shell endows the silicified fibrils with large bending rigidity, reflected in hydrogels with elasticity three orders of magnitude beyond conventional amyloid fibril hydrogels. A constitutive theoretical model is proposed that, despite its simplicity, quantitatively interprets the nonmonotonic dependence of the gel elasticity upon the filaments bundling promoted by shear stresses. The application of these hybrid silica-amyloid hydrogels is demonstrated on the fabrication of mechanically stable aerogels generated via sequential solvent exchange, supercritical [Formula: see text] removal, and calcination of the amyloid core, leading to aerogels of specific surface area as high as 993 [Formula: see text]/g, among the highest values ever reported for aerogels. We finally show that the scope of amyloid hydrogels can be expanded considerably by generating double networks of amyloid and hydrophilic polymers, which combine excellent stiffness and toughness beyond those of each of the constitutive individual networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.