Evidence map›Paper›PMID 30782781›Full record

ArticleThe Journal of cell biology2019

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.

Nicole Scholz, Nadine Ehmann, Divya Sachidanandan, Cordelia Imig, Benjamin H Cooper, Olaf Jahn, Kerstin Reim, Nils Brose, Jutta Meyer, Marius Lamberty and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Active forgetting requires Sickie function in a dedicated dopamine circuit inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Review
  8. Article
  9. The function of VAMP2 in mediating membrane fusion: An overview.Frontiers in molecular neuroscience · 2022
    Review
  10. TheGenome research · 2021
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Nicole ScholzInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-8087-8451
Nadine EhmannInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.
Divya SachidanandanInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-8219-8177
Cordelia ImigDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0001-7351-8706
Benjamin H CooperDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0003-2374-9922
Olaf JahnProteomics Group, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0002-3397-8924
Kerstin ReimDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0003-0938-8534
Jutta MeyerDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Marius LambertyInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-9618-6644
Steffen AltrichterInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.
Anne BormannRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Leipzig University, Leipzig, Germany.
Stefan HallermannCarl Ludwig Institute for Physiology, Leipzig University, Leipzig, Germany.ORCID 0000-0001-9376-7048
Martin PauliInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.
Manfred HeckmannInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany.
Christian StigloherImaging Core Facility, Biocenter, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-6941-2669
Tobias LangenhanInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany tobias.langenhan@gmail.com.ORCID 0000-0002-9061-3809
Robert J KittelInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany rjkittel@me.com.ORCID 0000-0002-9199-4826
University of Würzburg · DEMax Planck Institute of Experimental Medicine · DELeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information processing by the nervous system depends on neurotransmitter release from synaptic vesicles (SVs) at the presynaptic active zone. Molecular components of the cytomatrix at the active zone (CAZ) regulate the final stages of the SV cycle preceding exocytosis and thereby shape the efficacy and plasticity of synaptic transmission. Part of this regulation is reflected by a physical association of SVs with filamentous CAZ structures via largely unknown protein interactions. The very C-terminal region of Bruchpilot (Brp), a key component of the

Indexed as

Neuronal PlasticityAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsDrosophila melanogasterDrosophila ProteinsMiceMice, KnockoutNerve Tissue ProteinsProtein DomainsSNARE ProteinsSynaptic VesiclesAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportBRP protein, DrosophilaCplx3 protein, mousecpx protein, DrosophilaDrosophila ProteinsNerve Tissue ProteinsSNARE Proteins

Identifiers

PMID30782781
PMCPMC6400551
OpenAlexW2951474293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.