ArticleBMJ open2019
Incidence of hospitalisation for severe complications of influenza virus infection in Japanese patients between 2012 and 2016: a cross-sectional study using routinely collected administrative data.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- High Clinical Burden of Influenza Disease in Adults Aged ≥ 65 Years: Can We Do Better? A Systematic Literature Review.Advances in therapy · 2023Pooled it
- Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis.PLoS medicine · 2021Pooled it
- Incidence of RSV- and Influenza-Associated Hospitalizations With Community-Acquired Pneumonia and Other Acute Respiratory Infection Among Adults in Japan in 2022-2024: APSG-J2 Study.Influenza and other respiratory viruses · 2026Article
- Cost-Effectiveness Analysis of Influenza Treatments in Japan Using a Transmission Model: The Impact of Baloxavir and Oseltamivir Shares.Infectious diseases and therapy · 2025Article
- Influenza A as a Potential Mimic of Central Nervous System Infections in Pediatric Patients.Turkish archives of pediatrics · 2025Article
- Segmenting attitudes toward vaccination - behavioral insights into influenza vaccination refusal in Romania.Germs · 2024Article
- Contribution of immunoglobulin products in influencing seasonal influenza infection and severity in antibody immune deficiency patients receiving immunoglobulin replacement therapy.Frontiers in immunology · 2024Review
- Characteristics and outcome of influenza-associated encephalopathy/encephalitis among children in China.Clinics (Sao Paulo, Brazil) · 2024Article
- Antibiotic prescription for outpatients with influenza and subsequent hospitalisation: A cohort study using insurance data.Influenza and other respiratory viruses · 2023Article
- COVID-19 in Patients with Pre-Existing Interstitial Lung Disease: Potential Value of a Steroid-Based Treatment Strategy.Journal of clinical medicine · 2023Article
- Seasonal Influenza Vaccine Intention among Nurses Who Have Been Fully Vaccinated against COVID-19: Evidence from Greece.Vaccines · 2023Article
- The correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer.Frontiers in microbiology · 2023Article
- Burden of severe illness associated with laboratory confirmed influenza in adults aged 50-64 years: A rapid review.Influenza and other respiratory viruses · 2022Review
- Article
- Dearth of influenza among older adults admitted with respiratory symptoms in Malaysia during the coronavirus disease 2019 pandemic in 2021.Frontiers in medicine · 2022Article
- Prevalence, Predictive Factors, and Outcomes of Respiratory Failure in Children With Pneumonia Admitted in a Developing Country.Frontiers in pediatrics · 2022Article
- Prevalence, Risk Factors, and Outcomes of Influenza-Associated Neurologic Complications in Children.The Journal of pediatrics · 2021Article
- Clinical and virological outcomes with baloxavir compared with oseltamivir in pediatric patients aged 6 to < 12 years with influenza: an open-label, randomized, active-controlled trial protocol.BMC infectious diseases · 2021Article
- Behavioral changes adopted to constrain COVID-19 in Japan: What are the implications for seasonal influenza prevention and control?Global health & medicine · 2021Review
- Encouraging Cross-Disciplinary Collaboration and Innovation in Epidemiology in Japan.Frontiers in public health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo calculate the incidence of hospitalisation due to acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy among influenza-positive patients in Japan, where point-of-care tests are routinely used to diagnose influenza.
designA cross-sectional study using routinely collected data.
settingJapanese clinics and hospitals between 2012 and 2016.
participantsJapanese patients aged 0-74 years diagnosed with influenza by a rapid test in employment-related health insurance records. PRIMARY OUTCOME MEASURES: Incidence of hospitalisation per 100 000 influenza-positive episodes.
resultsWe included over 16 million influenza-positive episodes, 1.0% of whom were hospitalised. Of these, 3361 were acute respiratory failure, 27 253 pneumonia, 18 ARDS, 2603 febrile seizure and 159 encephalitis/encephalopathy. The percentage of hospitalisations by age was 2.96% of patients aged 0-1 years, 0.77% aged 2-5, 0.51% aged 6-12, 0.78% aged 13-18, 1.36% aged 19-44, 1.19% aged 45-64, and 2.21% aged 65-74. The incidence of hospitalisations from these five complications combined was highest in influenza-positive patients aged 0-1 years (943 per 100 000) compared with 307 in those aged 2-5 years and 271 in those aged 65-74 years. For pneumonia, the incidence was highest for influenza-positive patients aged 0-5 years and 65 years or more. There were statistically significant decreasing trends over the years in the incidence of all-cause hospitalisations, pneumonia and febrile seizures.
conclusionsJapanese administrative data revealed that 1.0% of influenza-positive patients aged under 75 years were hospitalised. Male patients had a higher incidence of pulmonary complications and febrile seizures. Children aged 0-5 years and adults aged 65-74 years were at high risk of being admitted to hospital for pneumonia.
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