ArticleBMJ open2019
Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: a population-based study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Global prevalence of neonatal mortality in preterm infants: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial.European journal of pediatrics · 2025Trial
- Vulnerable newborn types: Analysis of population-based registries for 165 million births in 23 countries, 2000-2021.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Preterm birth in Latvia: Two-decade national trends, structure, and risk factors.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Born too soon: global epidemiology of preterm birth and drivers for change.Reproductive health · 2025Article
- Extreme Temperature Exposure and Risks of Preterm Birth Subtypes Based on a Nationwide Survey in China.Environmental health perspectives · 2023Article
- Comparison of Neonatal Morbidity and Mortality Following Spontaneous and Medically Indicated Preterm Births: A Retrospective Population-Based Study Using Data from the Slovenian National Perinatal Information System 2013-2018.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Article
- First-trimester urinary extracellular vesicles as predictors of preterm birth: an insight into immune programming.Frontiers in cell and developmental biology · 2023Article
- Observational data from the adalimumab post-marketing PYRAMID registry of patients with Crohn's disease who became pregnant: A post hoc analysis.United European gastroenterology journal · 2022Article
- Chinese Neonatal Network: a national protocol for collaborative research and quality improvement in neonatal care.BMJ open · 2022Article
- Maternal H-antigen secretor status is an early biomarker for potential preterm delivery.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Team-Based Care of Women With Cardiovascular Disease From Pre-Conception Through Pregnancy and Postpartum: JACC Focus Seminar 1/5.Journal of the American College of Cardiology · 2021Review
- Iatrogenic vs. Spontaneous Preterm Birth: A Retrospective Study of Neonatal Outcome Among Very Preterm Infants.Frontiers in neurology · 2021Article
- Modelling mortality within 28 days among preterm infants at a tertiary hospital in Lusaka, Zambia: a retrospective review of hospital-based records.The Pan African medical journal · 2021Article
- Accelerated fetal growth in early pregnancy and risk of preterm birth: a prospective cohort study.BMC pregnancy and childbirth · 2020Article
- Neonatal Sepsis Diagnosis Decision-Making Based on Artificial Neural Networks.Frontiers in pediatrics · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAfter a decade of increase, the preterm birth (PTB) rate has declined in the USA since 2006, with the largest decline at late preterm (34-36 weeks). We described concomitant changes in gestational age-specific rates of neonatal mortality and morbidity following spontaneous and clinician-initiated PTB among singleton infants. DESIGN, SETTING AND
participantsThis retrospective population-based study included 754 763 singleton births in Washington State, USA, 2004-2013, using data from birth certificates and hospitalisation records. PTB subtypes included preterm premature rupture of membranes (PPROM), spontaneous onset of labour and clinician-initiated delivery. OUTCOME MEASURES: The primary outcomes were neonatal mortality and a composite outcome including death or severe neonatal morbidity. Temporal trends in the outcomes and individual morbidities were assessed by PTB subtype. Logistic regression yielded adjusted odds ratios (AOR) per 1 year change in outcome and 95% CI.
resultsThe rate of PTB following PPROM and spontaneous labour declined, while clinician-initiated PTB increased (all p<0.01). Overall neonatal mortality remained unchanged (1.3%; AOR 0.99, CI 0.95 to 1.02), though gestational age-specific mortality following clinician-initiated PTB declined at 32-33 weeks (AOR 0.85, CI 0.74 to 0.97) and increased at 34-36 weeks (AOR 1.10, CI 1.01 to 1.20). The overall rate of the composite outcome increased (from 7.9% to 11.9%; AOR 1.06, CI 1.05 to 1.08). Among late preterm infants, combined mortality or severe morbidity increased following PPROM (AOR 1.13, CI 1.08 to 1.18), spontaneous labour (AOR 1.09, CI 1.06 to 1.13) and clinician-initiated delivery (AOR 1.10, CI 1.07 to 1.13). Neonatal sepsis rates increased among all preterm infants (AOR 1.09, CI 1.08 to 1.11).
conclusionsTiming of obstetric interventions is associated with infant health outcomes at preterm. The temporal decline in late PTB among singleton infants was associated with increased mortality among late preterm infants born following clinician-initiated delivery and increased combined mortality or severe morbidity among all late preterm infants, mainly due to increased rate of sepsis.
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