ArticleBMJ open2019
Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic value of NLR, SII, PCT, and PLR in sepsis and septic shock: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis.BMC emergency medicine · 2024Pooled it
- Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis.BioMed research international · 2022Pooled it
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Prognostic Value of the C-Reactive Protein × Platelet-to-Lymphocyte Ratio for 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study.Health science reports · 2026Article
- Are Inflammatory Biomarkers at ICU Discharge Still Predictive of Post-ICU Mortality in Sepsis and Septic Shock? A Retrospective, Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Neutrophil-Lymphocyte-Platelet Ratio for Predicting Bacteremia in Immunosuppressed Cancer Patients: A Retrospective Diagnostic Accuracy Study.Biomedicines · 2026Article
- Postoperative red cell distribution width to platelet ratio is related to cardiac surgery-associated acute kidney injury.BMC cardiovascular disorders · 2026Article
- Clinical and Microbiological Profile of Hospital-Acquired and Ventilator-Associated Pneumonia in Critically Ill Patients: A Retrospective Observational Study.Antibiotics (Basel, Switzerland) · 2026Article
- Predictive Value of Platelet-Based Indexes for Mortality in Sepsis.Biomedicines · 2026Article
- Platelet to lymphocyte ratio in the healthy population of Vojvodina.Journal of medical biochemistry · 2026Article
- Early increase in red cell distribution width-to-platelet ratio is associated with poor prognosis in sepsis patients: a retrospective cohort study.Frontiers in medicine · 2026Article
- Article
- dNLR, NLR, and NMLR as differential markers for assessing severity and sepsis in emphysematous pyelonephritis.Frontiers in medicine · 2026Article
- Clinical and laboratory predictors of mortality inAnnals of medicine · 2025Observational
- Higher neutrophil-lymphocyte ratio predicts poor response to repetetive transcranial magnetic stimulation(rTMS) in treatment resistant depression.European archives of psychiatry and clinical neuroscience · 2025Article
- Sex differences in peer victimization and suicidal ideation among adolescents: a cross-sectional study.BMC public health · 2025Article
- Disease duration-stratified associations of thyroid hormone levels with psychopathology in hospitalized patients with schizophrenia: A cross-sectional study.World journal of psychiatry · 2025Article
- The Diagnostic and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Urosepsis.Medicina (Kaunas, Lithuania) · 2025Observational
- Predictors of mortality inThe Journal of international medical research · 2025Observational
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe role of platelet-to-lymphocyte ratio (PLR) as an indicator of inflammation has been the focus of research recently. We aimed to investigate the
designA retrospective cohort study. SETTING AND
participantsData were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III database. Data on 5537 sepsis patients were analysed.
methodsLogistic regression was used to explore the association between PLR and hospital mortality. Subgroup analyses were performed based on vasopressor use, acute kidney injury (AKI) and a Sequential Organ Failure Assessment (SOFA) score >10.
resultsIn the logistic model with linear spline function, a PLR >200 was significantly (OR 1.0002; 95% CI 1.0001 to 1.0004) associated with mortality; the association was
conclusionsHigh PLRs at admission were associated with an increased risk of mortality. In patients with vasopressor use, AKI or a SOFA score >10, this association was
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