Evidence map›Paper›PMID 30782657›Full record

ArticlemBio2019

Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response.

Shannon G Murphy, Laura Alvarez, Myfanwy C Adams, Shuning Liu, Joshua S Chappie, Felipe Cava, Tobias Dörr

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. A periplasmic zinc capture protein enhances the resistance ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. A single point mutation is sufficient to driveJournal of bacteriology · 2025
    Article
  5. A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Non-O1/Non-O139Microorganisms · 2024
    Review
  8. Article
  9. Review
  10. A conserved zinc-binding site inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Zinc acquisition and its contribution toFrontiers in cellular and infection microbiology · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shannon G MurphyDepartment of Microbiology, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-4544-1400
Laura AlvarezLaboratory for Molecular Infection Medicine, Department of Molecular Biology, Umeå University, Umeå, Sweden.
Myfanwy C AdamsDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Shuning LiuDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
Joshua S ChappieDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Felipe CavaLaboratory for Molecular Infection Medicine, Department of Molecular Biology, Umeå University, Umeå, Sweden.
Tobias DörrDepartment of Microbiology, Cornell University, Ithaca, New York, USA tdoerr@cornell.edu.ORCID 0000-0003-3283-9161
Cornell University · USUmeå University · SE

Funding

Cell envelope stress responses and the mechanism of antibiotic tolerance in Gram-negative pathogensR01AI143704 · NIAID · CORNELL UNIVERSITY · PI DOERR, TOBIAS · 2019 to 2023
$2.0M
NIAID NIH HHS R01 AI143704
6 · The paper itself

Abstract

The cell wall is a strong, yet flexible, meshwork of peptidoglycan (PG) that gives a bacterium structural integrity. To accommodate a growing cell, the wall is remodeled by both PG synthesis and degradation.

Indexed as

Gene Expression Regulation, BacterialCoenzymesDNA Transposable ElementsEndopeptidasesGene Expression ProfilingHydrolysisMutagenesis, InsertionalPeptidoglycanTranscriptional ActivationVibrio choleraeZincCoenzymesDNA Transposable ElementsEndopeptidasesPeptidoglycanZinccell wallGram-negativehydrolasemetalloproteinspeptidoglycanVibrio choleraezinc starvation

Identifiers

PMID30782657
PMCPMC6381278
OpenAlexW2952424119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.