Evidence map›Paper›PMID 30782633›Full record

ArticleJournal of bacteriology2019

Rcs Phosphorelay Activation in Cardiolipin-Deficient Escherichia coli Reduces Biofilm Formation.

Julia F Nepper, Yin C Lin, Douglas B Weibel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Dark Side ofJournal of the American Chemical Society · 2026
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  9. Development and Regulation of the Extreme Biofilm Formation ofInternational journal of molecular sciences · 2023
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  12. Review
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  15. Cardiolipin aids in lipopolysaccharide transport to the gram-negative outer membrane.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Julia F NepperDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Yin C LinDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Douglas B WeibelDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA douglas.weibel@wisc.edu.
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm formation is a complex process that requires a number of transcriptional, proteomic, and physiological changes to enable bacterial survival. The lipid membrane presents a barrier to communication between the machinery within bacteria and the physical and chemical features of their extracellular environment, and yet little is known about how the membrane influences biofilm development. We found that depleting the anionic phospholipid cardiolipin reduces biofilm formation in

Indexed as

Signal TransductionBiofilmsCardiolipinsCell MembraneCholic AcidsEscherichia coliEscherichia coli ProteinsProtein TransportStress, PhysiologicalCardiolipinscholanic acidCholic AcidsEscherichia coli ProteinsrcsF protein, E colianionic phospholipidsbiofilmcardiolipincell membranesEscherichia coliflagellaphosphoinositol kinaseprotein translocationRcs signaling

Identifiers

PMID30782633
PMCPMC6456859
OpenAlexW2910299820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.