ArticleBlood2019
The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
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- The impact of donor and recipient age on post-transplantation clonality in murine hematopoiesis.Stem cells (Dayton, Ohio) · 2025Article
- Clonal hematopoiesis in myeloid malignancies and solid tumors.Nature cancer · 2025Review
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- Neurobeachin regulates hematopoietic progenitor differentiation and survival by modulating Notch activity.Blood advances · 2024Article
- Counting blood precursors.eLife · 2024Article
- Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitors.Experimental hematology · 2024Review
- Replication stress as a driver of cellular senescence and aging.Communications biology · 2024Review
- Tissue mosaicism following stem cell aging: blood as an exemplar.Nature aging · 2024Review
- The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024Review
- Donor Cell Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation.Journal of hematology · 2023Article
- Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches.HemaSphere · 2023Review
- Stem cell decoupling underlies impaired lymphoid development during aging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.Nature communications · 2023Article
- Cell competition in development, homeostasis and cancer.Nature reviews. Molecular cell biology · 2023Review
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9 authors at 1 institution in 1 country.
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Abstract
Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state hematopoiesis throughout mammalian life is lacking. Previous efforts relied on transplantation of "barcoded" hematopoietic stem cells (HSCs) to track the contribution of HSC clones to reconstituted blood. However, ex vivo manipulation and transplantation alter HSC function and thus may not reflect the biology of steady-state hematopoiesis. Using a noninvasive in vivo color-labeling system, we report the first comprehensive analysis of the changing global clonal complexity of steady-state hematopoiesis during the natural murine lifespan. We observed that the number of clones (ie, clonal complexity) supporting the major blood and bone marrow hematopoietic compartments decline with age by ∼30% and ∼60%, respectively. Aging dramatically reduced HSC in vivo-repopulating activity and lymphoid potential while increasing functional heterogeneity. Continuous challenge of the hematopoietic system by serial transplantation provoked the clonal collapse of both young and aged hematopoietic systems. Whole-exome sequencing of serially transplanted aged and young hematopoietic clones confirmed oligoclonal hematopoiesis and revealed mutations in at least 27 genes, including nonsense, missense, and deletion mutations in
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.