Evidence map›Paper›PMID 30782154›Full record

ArticleJournal of nanobiotechnology2019

Chlorotoxin peptide-functionalized polyethylenimine-entrapped gold nanoparticles for glioma SPECT/CT imaging and radionuclide therapy.

Lingzhou Zhao, Yujie Li, Jingyi Zhu, Na Sun, Ningning Song, Yan Xing, He Huang, Jinhua Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
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  10. Small science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lingzhou ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Yujie LiDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Jingyi ZhuState Key Laboratory of Material-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Na SunDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Ningning SongDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Yan XingDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
He HuangState Key Laboratory of Material-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China. huangh@njtech.edu.cn.
Jinhua ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China. zhaojinhua1963@126.com.

Funding

National Natural Science Foundation of China 21807059National Natural Science Foundation of China 81671712Natural Science Foundation for Colleges and Universities in Jiangsu Province 17KJB350005Natural Science Foundation of Jiangsu Province BK20180711Shanghai Sailing Program 16YF1409300
6 · The paper itself

Abstract

backgroundMalignant glioma is the most common and deadliest brain cancer due to the obstacle from indistinct tumor margins for surgical excision and blood brain barrier (BBB) for chemotherapy. Here, we designed and prepared multifunctional polyethylenimine-entrapped gold nanoparticles (Au PENPs) for targeted SPECT/CT imaging and radionuclide therapy of glioma.

resultsPolyethylenimine was selected as a template for sequential modification with polyethylene glycol (PEG), glioma-specific peptide (chlorotoxin, CTX) and 3-(4-hydroxyphenyl)propionic acid-OSu (HPAO), and were then used to entrap gold nanoparticles (Au NPs). After

conclusionsOur results indicated that the formed nanosystem had the significant potential to be applied for glioma targeted diagnosis and therapy.

Indexed as

Drug Delivery SystemsMetal NanoparticlesScorpion VenomsAnimalsCell Line, TumorCell SurvivalDisease Models, AnimalGliomaGoldHumansMaleMicePeptidesPolyethyleneimineRatsRats, Sprague-DawleyChlorotoxinGoldPeptidesPolyethyleneimineScorpion VenomsChlorotoxinGliomaGold nanoparticlesPolyethyleneimineRadionuclide therapySPECT/CT imaging

Identifiers

PMID30782154
PMCPMC6380014

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.