ArticleBMC infectious diseases2019
Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Article
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- Distribution of Staphylococcus aureus drug resistance genes, biofilm formation and cell wall characteristics in dairy cattle from dairy farms in Northeast China.BMC veterinary research · 2025Article
- Emergence of Multidrug-Resistant and Biofilm-ProducingMicroorganisms · 2025Article
- Pristinamycin-antibiotic combinations against methicillin-resistant Staphylococcus aureus recovered from skin infections.BMC infectious diseases · 2025Article
- Structural studies on ribosomes of differentially macrolide-resistantLife science alliance · 2025Article
- Emerging antibiotic resistance by various novel proteins/enzymes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Addressing urgent priorities in antibiotic development: insights from WHO 2023 antibacterial clinical pipeline analyses.The Lancet. Microbe · 2025Review
- Exploring the repurposed role of solithromycin as an antivirulence agent againstFrontiers in microbiology · 2025Article
- Clindamycin-resistant among Staphylococcus aureus: Investigation into phenotypic and genotypic profiles.PloS one · 2025Article
- Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and KBMC microbiology · 2024Article
- Investigating genomic diversity ofFrontiers in microbiology · 2024Article
- Epitranscriptional m6A modification of rRNA negatively impacts translation and host colonization in Staphylococcus aureus.PLoS pathogens · 2024Article
- Regulation Transcriptional of Antibiotic Resistance Genes (ARGs) in Bacteria Isolated from WWTP.Current microbiology · 2023Article
- New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens.Antimicrobial agents and chemotherapy · 2023Article
- Vancomycin Resistance inMicroorganisms · 2022Review
- Prevalence and Clindamycin Resistance Profile ofInterdisciplinary perspectives on infectious diseases · 2022Article
- Mechanisms of Resistance to Macrolide Antibiotics amongAntibiotics (Basel, Switzerland) · 2021Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSolithromycin, the fourth generation of ketolides, has been demonstrated potent antibacterial effect against commonly-isolated gram-positive strains. However, Staphylococcus aureus (S. aureus) strains with a higher solithromycin MIC have already been emerged, the mechanism of which is unknown.
methodsAntimicrobial susceptibility test was performed on 266 strains of S. aureus. The antibiotic resistance phenotype of erm-positive strain was determined by D-zone test. Spontaneous mutation frequency analysis was performed to compare the risk levels for solithromycin resistance among different strains. Efflux pumps and mutational analysis of ribosomal fragments as well as erm(B) gene domains were detected. Quantitative reverse transcription polymerase chain reaction was conducted to compare the transcriptional expression of the erm gene between the constitutive macrolide-lincosamide-streptogramin B (cMLSB)- and inducible MLSB (iMLSB)-phenotypes.
resultsIn the erm-positive S. aureus strains, the minimum inhibitory concentration (MIC)
conclusionsThe reduced susceptibility to solithromycin by S. aureus was associated with the cMLSB resistance phenotype mediated by erm.
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