Evidence map›Paper›PMID 30782119›Full record

ArticleBMC microbiology2019

Purification and characterization of actinomycins from Streptomyces strain M7 active against methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus.

Manish Sharma, Rajesh Kumari Manhas

Open access · goldAbstract read
In one paragraph

Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Draft genome sequence data ofData in brief · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Actinomycin Analogs from Soil-DerivedLife (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Actinomycins from Soil-InhabitingMolecules (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. PeerJ · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Manish SharmaDepartment of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Rajesh Kumari ManhasDepartment of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. rkmanhas@rediffmail.com.ORCID 0000-0002-6445-8294
Guru Nanak Dev University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increased rate of resistance among two highly concerned pathogens i.e. methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) necessitates the discovery of novel anti-MRSA and anti-VRE compounds. In microbial drug discovery, Streptomyces are well known source of two-thirds of natural antibiotics used clinically. Hence, screening of new strains of streptomycetes is the key step to get novel bioactive compounds with antimicrobial activity against drug resistant bacteria.

resultsIn the present study, Streptomyces antibioticus strain M7, possessing potent antibacterial activity against different pathogenic bacteria, was isolated from rhizospheric soil of Stevia rebudiana. 16S rRNA sequence of M7 (1418 bp) showed 96.47-100% similarity with different Streptomyces spp. and the maximum similarity (100%) was observed with Streptomyces antibioticus NBRC 12838

conclusionsThis study demonstrates that actinomycins V, X

Indexed as

Anti-Bacterial AgentsDactinomycinDrug DiscoveryDrug Resistance, Multiple, BacterialMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPhylogenyRhizosphereRNA, Ribosomal, 16SSoil MicrobiologySteviaStreptomycesVancomycin-Resistant Enterococciactinomycin XAnti-Bacterial AgentsDactinomycinRNA, Ribosomal, 16SActinobacteriumAntibacterialMICMRSAVRE

Identifiers

PMID30782119
PMCPMC6381723
OpenAlexW2921939682

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.