Evidence map›Paper›PMID 30782091›Full record

ArticleJournal of dental research2019

Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health.

C Dawes, D T W Wong

Abstract readHistorical Article
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Saliva sample for the massive screening of SARS-CoV-2 infection: a systematic review.Oral surgery, oral medicine, oral pathology and oral radiology · 2021
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Salivary Proteome Role in Infection and Immunity.Advances in experimental medicine and biology · 2026
    Review
  11. Article
  12. Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

C Dawes1 Department of Oral Biology, Dental College, University of Manitoba, Winnipeg, MB, Canada.
D T W Wong2 Center for Oral/Head and Neck Oncology Research, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA, USA.ORCID 0000-0002-0290-2206

Funding

EFIRM Liquid Biopsy Research Laboratory: Early Lung Cancer AssessmentU01CA233370 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABERLE, DENISE R., HSU, WILLIAM · 2018 to 2025
$8.0M
Oral Fluid NanoSensor Test (OFNASET)U01DE017790 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2006 to 2010
$7.3M
Human Salivary ProteomeU01DE016275 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2004 to 2007
$5.5M
Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive ValidationU01DE017593 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2011 to 2014
$4.3M
UCLA Collaborative Oral Fluid Diagnostic Research CenterU01DE015018 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2002 to 2005
$4.0M
Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH3TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2015 to 2017
$2.7M
Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's SyndromeR01DE017593 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2006 to 2010
$2.1M
Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)R01DE019255 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORR, SVEN-ULRIK, HORVATH, STEVE · 2009 to 2010
$1.8M
Salivary Biomarkers for Early Oral Cancer DetectionR01DE017170 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2008 to 2011
$1.5M
Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC PatientsUH3CA206126 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIA, DAVID S., SOO HOO, GUY · 2019 to 2021
$1.2M
Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH2TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2013 to 2014
$996k
Collection, Stabilization and Storage of Saliva Samples for Cancer ResearchR21CA126733 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2008 to 2009
$381k
NCATS NIH HHS UH2 TR000923NCATS NIH HHS UH3 TR000923NCI NIH HHS R21 CA126733NCI NIH HHS R21 CA177902NCI NIH HHS U01 CA233370NCI NIH HHS UH2 CA206126NCI NIH HHS UH3 CA206126NIDCR NIH HHS R01 DE017170NIDCR NIH HHS R01 DE017593NIDCR NIH HHS R01 DE019255NIDCR NIH HHS U01 DE015018NIDCR NIH HHS U01 DE016275NIDCR NIH HHS U01 DE017593NIDCR NIH HHS U01 DE017790
6 · The paper itself

Abstract

The objective of this article was to provide an account of some of the developments related to saliva over the first 100 years of the Journal of Dental Research and to outline some of the many biomarkers identified in saliva in the last few years. The first section covers findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology, and the role of saliva in maintaining oral health. The second section highlights salivary diagnostics, salivaomics, and saliva exosomics in the context of the emerging theme of personalized and precision medicine.

Indexed as

Calcium PhosphatesBiomarkersDiagnosis, OralHistory, 20th CenturyHistory, 21st CenturyHumansOral HealthPeriodicals as TopicPrecision MedicineSalivaBiomarkerscalcium phosphateCalcium Phosphatesexosomicsparotidproteomicssalivaomicssubmandibular/sublingualtranscriptomics

Identifiers

PMID30782091
PMCPMC6900436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.