Evidence map›Paper›PMID 30782087›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2019

Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model.

Greene Donald Royster, Justine C Harris, Amanda Nelson, Yessenia Castro, R Patrick Weitzel, John Tisdale, Ryan J Heitmann, Alan H DeCherney, Erin F Wolff

Open access · greenAbstract read
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Memory regulatory T cells in pregnancy.Frontiers in immunology · 2023
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Greene Donald RoysterNational Institute of Child Health and Human Development, Bethesda, MD, USA.
Justine C HarrisNational Institute of Child Health and Human Development, Bethesda, MD, USA.
Amanda NelsonNational Institute of Child Health and Human Development, Bethesda, MD, USA.
Yessenia CastroUniversity of Texas at Austin, Austin, TX, USA.
R Patrick WeitzelNational Heart Lung and Blood Institute, Bethesda, MD, USA.
John TisdaleNIH, Bethesda, MD, USA.
Ryan J HeitmannMadigan Army Medical Center, Tacoma, WA, USA.
Alan H DeCherneyNational Institute of Child Health and Human Development, Bethesda, MD, USA.
Erin F WolffNational Institute of Child Health and Human Development, Bethesda, MD, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USMadigan Army Medical Center · USNational Heart Lung and Blood Institute · USNational Institutes of Health · USThe University of Texas at Austin · US

Funding

Reproductive Endocrinology And Infertility Clinical Training ProgramZIEHD008737 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HILL, MICAH · 2011 to 2025
$24.0M
6 · The paper itself

Abstract

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (T

Indexed as

AnimalsBirth RateDisease Models, AnimalEmbryo ImplantationFemaleImmunosuppressive AgentsInfertility, FemaleLive BirthLymphocyte DepletionMiceSirolimusT-Lymphocytes, RegulatoryImmunosuppressive AgentsSirolimusDEREGmurine modelrapamycinrecurrent implantation failureTregsT regulatory cellsunexplained infertility

Identifiers

PMID30782087
PMCPMC6949958
OpenAlexW2917536984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.