ArticleNutrients2019
Preventive Effect of YGDEY from Tilapia Fish Skin Gelatin Hydrolysates against Alcohol-Induced Damage in HepG2 Cells through ROS-Mediated Signaling Pathways.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Effects of dietary antimicrobial peptides on growth performance, antioxidant capacity, immune response and disease resistance of juvenile Nile tilapia (Frontiers in physiology · 2026Article
- Identification and Characterization of Glycine- and Proline-Rich Antioxidant Peptides From Antler Residues Based on Peptidomics, Machine Learning, and Molecular Docking.Food science & nutrition · 2025Article
- Article
- Antioxidant Peptide-Based Nanocarriers for Delivering Wound Healing Agents.Tissue engineering and regenerative medicine · 2025Article
- Antioxidant Peptides and Protein Hydrolysates from Tilapia: Cellular and In Vivo Evidences for Human Health Benefits.Foods (Basel, Switzerland) · 2024Review
- Effects ofFoods (Basel, Switzerland) · 2024Article
- Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells.Bioresources and bioprocessing · 2023Article
- Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways.Journal of Zhejiang University. Science. B · 2023Article
- Purification and Identification of Peptides from Oyster (Marine drugs · 2022Article
- Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration.Disease models & mechanisms · 2021Article
- The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol fromMarine drugs · 2021Article
- Intracellular ethanol-mediated oxidation and apoptosis in HepG2/CYP2E1 cells impaired by two active peptides from seahorse (Food science & nutrition · 2021Article
- Efficacy of Zhuyu Pill Intervention in a Cholestasis Rat Model: Mutual Effects on Fecal Metabolism and Microbial Diversity.Frontiers in pharmacology · 2021Article
- Antioxidant Mechanisms of the Oligopeptides (FWKVV and FMPLH) from Muscle Hydrolysate of Miiuy Croaker against Oxidative Damage of HUVECs.Oxidative medicine and cellular longevity · 2021Article
- CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.Scientific reports · 2020Article
- The Protective Effect of the Polysaccharide Precursor, D-Isofloridoside, fromMolecules (Basel, Switzerland) · 2020Article
- Cytoprotective Effect of Antioxidant Pentapeptides from the Protein Hydrolysate of Swim Bladders of Miiuy Croaker (International journal of molecular sciences · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to a previous study, YGDEY from tilapia fish skin gelatin hydrolysates has strong free radical scavenging activity. In the present study, the protective effect of YGDEY against oxidative stress induced by ethanol in HepG2 cells was investigated. First, cells were incubated with YGDEY (10, 20, 50, and 100 μM) to assess cytotoxicity, and there was no significant change in cell viability. Next, it was established that YGDEY decreased the production of reactive oxygen species (ROS). Western blot results indicated that YGDEY increased the levels of superoxide dismutase (SOD) and glutathione (GSH) and decreased the expression of gamma-glutamyltransferase (GGT) in HepG2 cells. It was then revealed that YGDEY markedly reduced the expressions of bax and cleaved-caspase-3 (c-caspase-3); inhibited phosphorylation of Akt, IκB-α, p65, and p38; and increased the level of bcl-2. Moreover, the comet assay showed that YGDEY effectively decreased the amount of ethanol-induced DNA damage. Thus, YGDEY protected HepG2 cells from alcohol-induced injury by inhibiting oxidative stress, and this may be associated with the Akt/nuclear factor-κB (NF-κB)/mitogen-activated protein kinase (MAPK) signal transduction pathways. These results demonstrate that YGDEY from tilapia fish skin gelatin hydrolysates protects HepG2 cells from oxidative stress, making it a potential functional food ingredient.
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