ReviewNutrients2019
Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA Damage.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association Between Maternal Diet and Frequency of Micronuclei in Mothers and Newborns: A Systematic Review.Nutrients · 2025Pooled it
- Pooled it
- Pooled it
- Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies.Redox biology · 2021Pooled it
- Trial
- Mitochondrial DNA DAMPs, Inflammation, and Insulin Sensitivity After Dietary Interventions in Adults with Type 2 Diabetes.Nutrients · 2025Article
- Adherence to the Mediterranean diet and colorectal cancer risk: a large case control study in the Moroccan population.Public health nutrition · 2025Article
- Review
- Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length.Current nutrition reports · 2024Review
- Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients.Frontiers in nutrition · 2024Review
- Influence of the Mediterranean Diet on Healthy Aging.International journal of molecular sciences · 2023Review
- Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients.Antioxidants (Basel, Switzerland) · 2022Article
- Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care.Nature reviews. Clinical oncology · 2022Review
- Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer's Disease than Amyloid or Tau.Journal of cellular immunology · 2022Article
- Observational
- Mediterranean diet and the hallmarks of ageing.European journal of clinical nutrition · 2021Review
- Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects.Antioxidants (Basel, Switzerland) · 2021Article
- Impact of 12-month cryopreservation on endogenous DNA damage in whole blood and isolated mononuclear cells evaluated by the comet assay.Scientific reports · 2021Article
- Editorial: Nutrition and the Hallmarks of Aging.The journal of nutrition, health & aging · 2021Article
- Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer's Disease.Journal of cellular immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mediterranean diet (MD) is characterized by high consumption of fruits, vegetables, cereals, potatoes, poultry, beans, nuts, lean fish, dairy products, small quantities of red meat, moderate alcohol consumption, and olive oil. Most of these foods are rich sources of bioactive compounds which may play a role in the protection of oxidative stress including DNA damage. The present review provides a summary of the evidence deriving from human intervention studies aimed at evaluating the impact of Mediterranean diet on markers of DNA damage, DNA repair, and telomere length. The few results available show a general protective effect of MD alone, or in combination with bioactive-rich foods, on DNA damage. In particular, the studies reported a reduction in the levels of 8-hydroxy-2'⁻deoxyguanosine and a modulation of DNA repair gene expression and telomere length. In conclusion, despite the limited literature available, the results obtained seem to support the beneficial effects of MD dietary pattern in the protection against DNA damage susceptibility. However, further well-controlled interventions are desirable in order to confirm the results obtained and provide evidence-based conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.