Evidence map›Paper›PMID 30781810›Full record

ArticleViruses2019

Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.

Fengling Feng, Jin Zhao, Pingchao Li, Ruiting Li, Ling Chen, Caijun Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fengling FengSchool of Life Sciences, University of Science and Technology of China (USTC), Hefei 230027, China. Feng_fengling@gibh.ac.cn.
Jin ZhaoSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 518107, China. zhaoj47@mail2.sysu.edu.cn.
Pingchao LiState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou 510530, China. li_pingchao@gibh.ac.cn.
Ruiting LiSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 518107, China. lirt9@mail2.sysu.edu.cn.
Ling ChenSchool of Life Sciences, University of Science and Technology of China (USTC), Hefei 230027, China. chen_ling@gibh.ac.cn.
Caijun SunSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 518107, China. suncaijun@mail.sysu.edu.cn.ORCID 0000-0002-2000-7053
Sun Yat-sen University · CNUniversity of Science and Technology of China · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased susceptibility to Ad infection, when compared with that of Ad-seronegative individuals. But the underlying mechanisms for this enhancement of viral infection are not completely clarified. In this study, we found that the efficacy of Ad infection into CD14+ monocytes was significantly decreased after CD3+ T lymphocytes depletion from PBMC samples of Ad-seropositive individuals. In contrast, adding virus-specific CD3+ T lymphocytes into PBMC samples of Ad-seronegative individuals resulted in a significant increase of infection efficacy. CD3+ T lymphocytes in PBMC samples from Ad-seropositive individuals were more sensitive to be activated by adenovirus stimulus, characterized by upregulation of multiple cytokines and activation markers and also enhancement of cell proliferation. Further studies demonstrated that GM-CSF and IL-4 can promote Ad infection by up-regulating the expression of scavenger receptor 1 (SR-A) and integrins αVβ5 receptor of CD14+ cells. And taken together, these results suggest a novel role of virus-specific T cells in mediating enhancement of viral infection, and provide insights to understand the pathogenesis and complicated interactions between viruses and host immune cells.

Indexed as

Adenoviridae InfectionsAdenoviruses, HumanCells, CulturedCytokinesGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-4Lipopolysaccharide ReceptorsMonocytesT-LymphocytesCD14 protein, humanCytokinesGranulocyte-Macrophage Colony-Stimulating FactorIL4 protein, humanInterleukin-4Lipopolysaccharide ReceptorsAdenovirusCytokinesMonocytesPathogenesisT lymphocytes

Identifiers

PMID30781810
PMCPMC6409799
OpenAlexW2911754011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.