Evidence map›Paper›PMID 30781793›Full record

ArticleNutrients2019

Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM.

Edwin R Miranda, Kelly N Z Fuller, Ryan K Perkins, Paul J Beisswenger, Sarah S Farabi, Lauretta Quinn, Jacob M Haus

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Advanced Glycation End Products and Inflammatory Cytokine Profiles in Maintenance Hemodialysis Patients After the Ingestion of a Protein-Dense Meal.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2023
    Article
  7. Article
  8. Article
  9. Plasma Levels of FreeNutrients · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Edwin R MirandaSchool of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA. edwinray@umich.edu.
Kelly N Z FullerDepartment of Molecular and Integrative Physiology, Kansas University Medical Center, 3901 Rainbow Blvd. Kansas City, KS 66160, USA. kfuller5@kumc.edu.
Ryan K PerkinsSchool of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA. ryperkin@umich.edu.
Paul J BeisswengerGeisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd., Hanover, NH 03755, USA. pjb@preventagehealthcare.com.
Sarah S FarabiEndocrine, Metabolism, & Diabetes, Division of Medicine, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl., Aurora, CO 80045, USA. schwarzsar@gmail.com.
Lauretta QuinnDepartment of Biobehavioral Health Science, University of Illinois at Chicago, 845 Damen Ave., Chicago, IL 60612, USA. lquinn18@gmail.com.
Jacob M HausSchool of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA. jmhaus@umich.edu.ORCID 0000-0002-8048-2470
Washtenaw Community College · USDartmouth College · USUniversity Medical Center · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Illinois Chicago · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Strategies and Functional Outcomes of Enhancing in Vivo Production of Soluble Rage IsoformsR01DK109948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAUS, JACOB M · 2016 to 2020
$3.1M
American Association of Diabetes Educators Foundation/Sigma Theta Tau International N/ANational Institute of Diabetes and Digestive and Kidney Diseases R01DK109948National Institutes of Health 5TL1TR000049-05NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK109948
6 · The paper itself

Abstract

Advanced glycation end products (AGEs) promote the development of diabetic complications through activation of their receptor (RAGE). Isoforms of soluble RAGE (sRAGE) sequester AGEs and protect against RAGE-mediated diabetic complications. We investigated the effect of an overnight fast on circulating metabolic substrates, hormones, AGEs, and sRAGE isoforms in 26 individuals with type 1 diabetes (T1DM). Blood was collected from 26 young (18⁻30 years) T1DM patients on insulin pumps before and after an overnight fast. Circulating AGEs were measured via LC-MS/MS and sRAGE isoforms were analyzed via ELISA. Glucose, insulin, glucagon, and eGFR

Indexed as

FastingAdultBiomarkersBlood GlucoseDiabetes Mellitus, Type 1FemaleGene Expression RegulationGlycation End Products, AdvancedHumansMaleMultivariate AnalysisOxidative StressProtein IsoformsReceptor for Advanced Glycation End ProductsYoung AdultBiomarkersBlood GlucoseGlycation End Products, AdvancedProtein IsoformsReceptor for Advanced Glycation End ProductsDiurnal FluxfastingmethylglyoxalRAGEsoluble RAGE

Identifiers

PMID30781793
PMCPMC6413006
OpenAlexW2911385805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.