ArticleViruses2019
Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Translational lessons from the balanced immune system in bats.Disease models & mechanisms · 2025Review
- SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals.Cell reports · 2025Article
- Conserved function of bat IRF7 in activating antiviral innate immunity: insights into the innate immune response in bats.Veterinary research · 2025Article
- Review
- Uncovering selection pressures on the IRF gene family in bats' immune system.Immunogenetics · 2025Article
- Studying bats using a One Health lens: bridging the gap between bat virology and disease ecology.Journal of virology · 2024Review
- Review
- Disease tolerance as immune defense strategy in bats: One size fits all?PLoS pathogens · 2024Review
- Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response.Cellular & molecular immunology · 2024Article
- A tale of endurance: bats, viruses and immune dynamics.Future microbiology · 2024Review
- Antiviral effects of interferon-stimulated genes in bats.Frontiers in cellular and infection microbiology · 2023Review
- Review
- Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells.Journal of virology · 2022Article
- From bats to pangolins: new insights into species differences in the structure and function of the immune system.Innate immunity · 2022Review
- A UV-LED module that is highly effective at inactivating human coronaviruses and HIV-1.Virology journal · 2022Article
- Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus.Virus genes · 2021Article
- Characterization of bat coronaviruses: a latent global threat.Journal of veterinary science · 2021Review
- Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19.Frontiers in cell and developmental biology · 2021Article
- The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection.Frontiers in pharmacology · 2021Review
- Coronavirus, the King Who Wanted More Than a Crown: From Common to the Highly Pathogenic SARS-CoV-2, Is the Key in the Accessory Genes?Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop signs of disease, we tested the hypothesis that MERS-CoV would replicate less efficiently in bat cells than in human cells because of its inability to subvert antiviral responses in bat cells. We infected human and bat (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.