ArticleNanomaterials (Basel, Switzerland)2019
Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release.
Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Hydrogel-based drug delivery systems for enhanced tumor therapy.RSC advances · 2026Review
- In vitro development and evaluation of chitosan-cellulose nanocrystal microspheres for controlled dexamethasone delivery in rheumatoid arthritis.Rheumatology international · 2025Article
- Current Paradigms and Future Challenges in Harnessing Nanocellulose for Advanced Applications in Tissue Engineering: A Critical State-of-the-Art Review for Biomedicine.International journal of molecular sciences · 2025Review
- Hydrogel technologies in andrology: advances in research and prospective applications.Frontiers in pharmacology · 2025Review
- Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights.IEEE open journal of engineering in medicine and biology · 2025Article
- Electro-Responsive Conductive Blended Hydrogel Patch.Polymers · 2023Article
- Topological Optimisation Structure Design for Personalisation of Hydrogel Controlled Drug Delivery System.Materials (Basel, Switzerland) · 2023Article
- Understanding Nanocellulose-Water Interactions: Turning a Detriment into an Asset.Chemical reviews · 2023Review
- Cellulose-Chitosan Functional Biocomposites.Polymers · 2023Review
- Engineering functional natural polymer-based nanocomposite hydrogels for wound healing.Nanoscale advances · 2022Review
- Review
- Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings.International journal of molecular sciences · 2022Article
- Dialdehyde Starch Nanocrystals as a Novel Cross-Linker for Biomaterials Able to Interact with Human Serum Proteins.International journal of molecular sciences · 2022Article
- Article
- Highly Flexibility, Powder Self-Healing, and Recyclable Natural Polymer Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Review
- Sustainable Chitosan-Dialdehyde Cellulose Nanocrystal Film.Materials (Basel, Switzerland) · 2021Article
- Antimicrobial and antihemolytic properties of a CNF/AgNP-chitosan film: A potential wound dressing material.Heliyon · 2021Article
- Article
- Preparation and characterization of enzymatically cross-linked gelatin/cellulose nanocrystal composite hydrogels.RSC advances · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
In this work, a novel nanocomposite hydrogel based on cellulose nanocrystal (CNC) and chitosan (CS) was fabricated and applied as a carrier for the controlled delivery of theophylline. CNC was firstly periodate-oxidized to obtain dialdehyde nanocellulose (DACNC). Then, chitosan was crosslinked using DACNC as both the matrix and crosslinker in different weight ratios, to fabricate CNC/CS composites. The prepared composites were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction pattern (XRD), scanning electron microscopy (SEM), zeta potential measurement and swelling ratio tests. FT-IR results confirmed the successful reaction between the free amino groups on chitosan and the aldehyde groups on DACNC. With the increase of chitosan percentage in the hydrogel, the isoelectric point was shifted towards an alkaline pH, which was probably caused by the higher content of free amino groups. The swelling ratio of the composite also increased, which may have been due to the decrease of crosslinking density. Because the swelling ratio of the drug-loaded hydrogels differed under varied pH values, the cumulative drug release percentage of the composite hydrogel was achieved to approximately 85% and 23% in the gastric (pH 1.5) and intestinal (pH 7.4) fluids, respectively. Therefore, CNC/CS hydrogel has application potential as a theophylline carrier.
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Registered trials
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