Evidence map›Paper›PMID 30781750›Full record

ArticleInternational journal of molecular sciences2019

MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.

Fei Jing, Yan Geng, Xin-Yi Xu, Hong-Yu Xu, Jin-Song Shi, Zheng-Hong Xu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.The International journal of developmental biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fei JingSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. 6161502006@vip.jiangnan.edu.cn.
Yan GengSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. gengyan@jiangnan.edu.cn.ORCID 0000-0001-8861-7686
Xin-Yi XuSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. 6171504010@stu.jiangnan.edu.cn.
Hong-Yu XuNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China. xhyhyhy@163.com.
Jin-Song ShiSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. shijs@163.com.
Zheng-Hong XuNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China. zhenghxu@jiangnan.edu.cn.
Jiangnan University · CN

Funding

China Postdoctoral Science Foundation 2018M640455Fundamental Research Funds for the Central Universities 1102050205181880Fundamental Research Funds for the Central Universities JUSRP21824National first-class discipline program of Light Industry Technology and Engineering LITE2018-11National Natural Science Foundation of China 31771514the Six talent peaks project in Jiangsu Province 2015-SWYY-006
6 · The paper itself

Abstract

Activated hepatic stellate cells (aHSCs) play a key role in liver fibrosis. During the regression of fibrosis, aHSCs are transformed into inactivated cells (iHSCs), which are quiescent lipid-containing cells and express higher levels of lipid-related genes, such as peroxisome proliferators-activated receptors gamma (PPARγ). Here, we investigated the role of

Indexed as

Gene Expression RegulationAdipogenesisAnimalsCarbon TetrachlorideCell TransdifferentiationDisease ProgressionGene Knockdown TechniquesHepatic Stellate CellsHumansLiver CirrhosisMaleMiceMice, Inbred C57BLMicroRNAsVacuolar Proton-Translocating ATPasesATP6V1C1 protein, humanAtp6v1c1 protein, mouseCarbon TetrachlorideMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, mouseVacuolar Proton-Translocating ATPasescell differentiationfibrosis regressionhepatic fibrosisperoxisome proliferators-activated receptors gamma (PPARγ)vacuolar adenosine triphosphatase (V-ATPase)

Identifiers

PMID30781750
PMCPMC6412626
OpenAlexW2914633192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.