Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate.

Wei-Jie Chen, Shuai-Bo Han, Zhen-Biao Xie, Hua-Shan Huang, Duo-Hua Jiang, Shan-Shan Gong, Qi Sun

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides.Molecules (Basel, Switzerland) · 2020
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5 · Who and what money

Authors and funding

7 authors.

Wei-Jie ChenJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. chenweijie9@126.com.

Shuai-Bo HanJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. hanshuaibo1@126.com.

Zhen-Biao XieJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. xiezhenbiao1@126.com.

Hua-Shan HuangJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. huanghuashan1@126.com.

Duo-Hua JiangJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. jiangduohua@126.com.

Shan-Shan GongJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. gongshanshan@jxstnu.edu.cn.

Qi SunJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China. sunqi@jxstnu.edu.cn.ORCID 0000-0001-5066-2975

Funding

Fellowship for Young Scientists of Jiangxi Province 2015BCB23009National Natural Science Foundation of China 21562021Natural Science Foundation of Jiangxi Province 20143ACB21014

6 · The paper itself

Abstract

A P(V)-N activation method based on nucleoside phosphoropiperidate/DCI system has been developed for improved synthesis of diverse UDP-furanoses. The reaction conditions including temperature, amount of activator, and reaction time were optimized to alleviate the degradation of UDP-furanoses to cyclic phosphates. In addition, an efficient and facile phosphoramidite route was employed for the preparation of furanosyl-1-phosphates.

Indexed as

ArabinoseImidazolesImino FuranosesNucleosidesPhosphatesPiperidinesUridine4,5-dicyanoimidazolearabinofuranoseArabinoseImidazolesImino FuranosesNucleosidesPhosphatespiperidinePiperidinesUridine4,5-dicyanoimidazolefuranosyl-1-phosphateNDP-sugarnucleoside phosphoropiperidateP(V)-N activation

Identifiers

PMID30781738

DOI10.3390/molecules24040655

PMCPMC6412210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.