ArticleInternational journal of environmental research and public health2019
Toxic Effects of TiO₂ NPs on Zebrafish.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- System-Dependent Ecotoxicological Effects of Anatase and Rutile Titanium Dioxide Nanoparticles Across Prokaryotic and Eukaryotic Test Models.Nanomaterials (Basel, Switzerland) · 2026Article
- TiOInternational journal of molecular sciences · 2026Article
- Evaluation of Oxidative Stress and Antioxidant Effects of Methylxanthines in Adult Zebrafish Exposed to Zinc Oxide Nanoparticles (ZnO-NPs).Medicina (Kaunas, Lithuania) · 2025Article
- Exploring Oxidative Stress Mechanisms of Nanoparticles Using Zebrafish (Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Antioxidant-related enzymes and peptides as biomarkers of metallic nanoparticles (eco)toxicity in the aquatic environment.Chemosphere · 2024Review
- Ultraviolet Filters: Dissecting Current Facts and Myths.Journal of clinical medicine · 2024Review
- Safe nanomaterials: from their use, application, and disposal to regulations.Nanoscale advances · 2024Review
- Toxicity of Titanium Dioxide-Cerium Oxide Nanocomposites to Zebrafish Embryos: A Preliminary Evaluation.Toxics · 2023Article
- Nutritional and ameliorative effects of dietary curcumin and its nano-silica and nano-zeolite encapsulated forms on growth, biochemical and fatty acid profile of common carp (Cyprinus carpio).Fish physiology and biochemistry · 2023Article
- Effects of carnosine on the embryonic development and TiOFrontiers in veterinary science · 2023Article
- Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users.F1000Research · 2023Review
- The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles inInternational journal of environmental research and public health · 2022Article
- Inhalation exposure to silver nanoparticles induces hepatic inflammation and oxidative stress, associated with altered renin-angiotensin system signaling, in Wistar rats.Environmental toxicology · 2022Article
- Effects of Metal Oxide Nanoparticles in Zebrafish.Oxidative medicine and cellular longevity · 2022Review
- Suitability of Nanoparticles to Face Benzo(a)pyrene-Induced Genetic and Chromosomal Damage inNanomaterials (Basel, Switzerland) · 2021Article
- Metal- and metal/oxide-based engineered nanoparticles and nanostructures: a review on the applications, nanotoxicological effects, and risk control strategies.Environmental science and pollution research international · 2021Review
- Adsorption of Cd to TiOCells · 2021Article
- Toxicity in vitro and in Zebrafish Embryonic Development of Gold Nanoparticles Biosynthesized UsingInternational journal of nanomedicine · 2021Article
- Opportunistic gill infection is associated with TiO2 nanoparticle-induced mortality in zebrafish.PloS one · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide nanoparticles (TiO₂ NPs) have become a widely used nanomaterial due to the photocatalytic activity and absorption of ultraviolet light of specific wavelengths. This study investigated the toxic effects of rutile TiO₂ NPs on zebrafish by examining its embryos and adults. In the embryo acute toxicity test, exposure to 100 mg/L TiO₂ NPs didn't affect the hatching rate of zebrafish embryos, and there was no sign of deformity. In the adult toxicity test, the effects of TiO₂ NPs on oxidative damage in liver, intestine and gill tissue were studied. Enzyme linked immunosorbent assay (ELISA) and fluorescence-based quantitative real-time reverse transcription PCR (qRT-PCR) were used to detect the three antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione S transferase (GSTs) in the above mentioned zebrafish organs at protein and gene levels. The results showed that long-term exposure to TiO₂ NPs can cause oxidative damage to organisms; and compared with the control group, the activity of the three kinds of enzyme declined somewhat at the protein level. In addition, long-term exposure to TiO₂ NPs could cause high expression of CAT, SOD and GSTs in three organs of adult zebrafish in order to counter the adverse reaction. The effects of long-term exposure to TiO₂ NPs to adult zebrafish were more obvious in the liver and gill.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.