Evidence map›Paper›PMID 30781722›Full record

ArticlePharmaceutics2019

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery.

Franciele Aline Bruinsmann, Stefania Pigana, Tanira Aguirre, Gabriele Dadalt Souto, Gabriela Garrastazu Pereira, Annalisa Bianchera, Laura Tiozzo Fasiolo, Gaia Colombo, Magno Marques, Adriana Raffin Pohlmann and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 126 citations in OpenAlex.

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  11. Nanoparticle-based Gene Therapy for Neurodegenerative Disorders.Mini reviews in medicinal chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Franciele Aline BruinsmannPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. fbruinsmann@gmail.com.ORCID 0000-0002-8833-7542
Stefania PiganaFood and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. stefania.pigana@studenti.unipr.it.
Tanira AguirrePrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS 900500-170, Brazil. tanira@ufcspa.edu.br.
Gabriele Dadalt SoutoPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. gabrieledadalt@gmail.com.
Gabriela Garrastazu PereiraPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. garrastazugp@gmail.com.
Annalisa BiancheraFood and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. annalisa.bianchera@unipr.it.ORCID 0000-0002-3160-9586
Laura Tiozzo FasioloFood and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. laura.tiozzofasiolo@studenti.unipr.it.ORCID 0000-0002-6561-8237
Gaia ColomboDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy. clmgai@unife.it.
Magno MarquesPrograma de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande, Rio Grande, RS 96203-000, Brazil. magnomarques@aol.com.ORCID 0000-0003-2451-1270
Adriana Raffin PohlmannPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. adriana.pohlmann@ufrgs.br.ORCID 0000-0001-5222-1807
Silvia Stanisçuaski GuterresPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. silvia.guterres@ufrgs.br.
Fabio SonvicoFood and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. fabio.sonvico@unipr.it.ORCID 0000-0001-7372-1456
University of Parma · ITUniversidade Federal do Rio Grande do Sul · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Rio Grande · BRUniversity of Ferrara · IT

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Ciências sem Fronteiras" BOLSA PESQUISADOR VISITANTE ESPECIAL-PVE 401196/2014-3
6 · The paper itself

Abstract

Drug delivery to the brain represents a challenge, especially in the therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult to exploit in the central nervous system (CNS). In the present work the physico⁻chemical, mucoadhesive, and permeability-enhancing properties of simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Lipid-core nanocapsules coated with chitosan (LNC

Indexed as

chitosanCNS disordersmucoadhesionnanocapsulesnasal permeabilitynose-to-brainsimvastatin

Identifiers

PMID30781722
PMCPMC6409859
OpenAlexW2913537223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.